An improved synthesis of (-)-martinellic acid via radical addition - Cyclization-elimination reaction of chiral oxime ether

被引：33

作者：

Miyata, O ^{[1
]}

Shirai, A ^{[1
]}

Yoshino, S ^{[1
]}

Takeda, Y ^{[1
]}

Sugiura, M ^{[1
]}

Naito, T ^{[1
]}

机构：

[1] Kobe Pharmaceut Univ, Higashinada Ku, Kobe, Hyogo 6588558, Japan

来源：

SYNLETT | 2006年 / 06期

关键词：

martinellic acid; radical reaction; oxime ether; asymmetric synthesis; pyrroloquinoline;

D O I：

10.1055/s-2006-939046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise formal synthesis of (-)-martinellic acid has been accomplished by preparing optically active dipyrroloquinoline as a key synthetic intermediate, which was prepared via the radical addition-cyclization-elimination of oxime ether carrying all unsaturated ester followed by two chemoselective reductions of the carbonyl groups.

引用

页码：893 / 896

页数：4

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