Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

被引：32

作者：

Chung, Hyunsoo ^{[1
]}

Cho, Hanbyoul ^{[2
]}

Perry, Candice ^{[1
]}

Song, Jaekyung ^{[2
]}

Ylaya, Kris ^{[1
]}

Lee, Heejeong ^{[3
]}

Kim, Jae-Hoon ^{[2
]}

机构：

[1] NCI, Tissue Array Res Program, Pathol Lab, Ctr Canc Res,NIH, Bethesda, MD 20892 USA

[2] Yonsei Univ, Coll Med, Inst Womens Life Med Sci, Dept Obstet & Gynecol, Seoul 135720, South Korea

[3] Catholic Univ Korea, Bucheon St Marys Hosp, Dept Pathol, Seoul, South Korea

来源：

BIOMARKERS | 2013年 / 18卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

Cervical cancer; ERp57; immunohistochemistry; survival; tissue microarray; CELL CARCINOMA; IMMUNE ESCAPE; TIME; COMPLEX;

D O I：

10.3109/1354750X.2013.827742

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: We investigated the clinical significance of ERp57 in the progression of cervical cancer. Methods: mRNA and protein expression of ERp57 in cervical neoplasias were examined. Results: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was downregulated compared to cervical intraepithelial neoplasias or normal tissues (p<0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018). Conclusions: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.

引用

页码：573 / 579

页数：7

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