THERMOREVERSIBLE HYDROGELS FROM HYDROLYTICALLY DEGRADABLE POLY(N-ISOPROPYLACRYLAMIDE)-POLY(ETHYLENE GLYCOL) TRIBLOCK COPOLYMER AND GELATIN

被引：0

作者：

Andrei, Maria ^{[1
]}

Draghici, Constantin ^{[2
]}

Teodorescu, Mircea ^{[1
]}

机构：

[1] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Dept Bioresources & Polymer Sci, Bucharest, Romania

[2] Costin D Nenitescu Romanian Acad, Ctr Organ Chem, Bucharest, Romania

来源：

UNIVERSITY POLITEHNICA OF BUCHAREST SCIENTIFIC BULLETIN SERIES B-CHEMISTRY AND MATERIALS SCIENCE | 2019年 / 81卷 / 01期

关键词：

poly(N-isopropylacrilamide); 5,6-benzo-2-methylene-1,3-dioxepane; gelatin; thermoresponsive polymer; degradable polymer; injectable hydrogel; POLY(ETHYLENE GLYCOL); INJECTABLE HYDROGEL; AQUEOUS-SOLUTIONS; WATER; POLYMERS; POLY(N-ISOPROPYLACRYLAMIDE-CO-5,6-BENZO-2-METHYLENE-1,3-DIOXEPANE); NETWORKS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel thermoreversible hydrogels that may find applications as biomaterials were prepared by adding gelatin to the aqueous solution of an ABA triblock copolymer with poly(ethylene glycol) middle block and poly(N-isopropylacrylamideco-5,6-benzo-2-methylene-1,3-dioxepane) as side blocks. The gelatin addition decreased the gelation temperature and improved the viscoelastic properties of the hydrogel, indicating the formation of a more resistant hydrogel, as a consequence of a semi-interpenetrating network structure formation. The increase of triblock copolymer concentration led to higher maximum values of the dynamic viscosity, storage modulus and viscous modulus. The mixed hydrogels partially degraded in phosphate buffer saline solution at 37 degrees C.

引用

页码：71 / 84

页数：14

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