Two new cytotoxic diterpenes from the rhizomes of Hedychium spicatum

被引：37

作者：

Reddy, P. Prabhakar ^{[1
]}

Rao, R. Ranga ^{[1
]}

Rekha, K. ^{[1
]}

Babu, K. Suresh ^{[1
]}

Shashidhar, J. ^{[2
]}

Shashikiran, G. ^{[2
]}

Lakshmi, V. Vijaya ^{[2
]}

Rao, J. Madhusudana ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Nat Prod Lab, Hyderabad 500607, Andhra Pradesh, India

[2] Natl Inst Nutr, Div Biochem, Hyderabad 500607, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 01期

关键词：

Hedychium spicatum; Gingiberaceae; Labdane diterpenes; Cytotoxic activity; CONSTITUENTS;

D O I：

10.1016/j.bmcl.2008.10.121

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phytochemical investigation of CHCl3 extract of the rhizomes of Hedychium spicatum led to the isolation of two new labdane-type diterpenes, compounds 1 and 2 along with five known compounds (3-7). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. In addition, all the isolates were tested for their cytotoxicity against the Colo-205 (Colo-cancer), A-431 (skin cancer), MCF-7 (breast cancer), A-549 (lung cancer) and Chinese hamster ovary cells (CHO). Two new compounds 1 and 2 were shown good cytotoxic activity. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：192 / 195

页数：4

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