Drug Delivery with a Calixpyrrole-trans-Pt(II) Complex

被引：68

作者：

Cafeo, Grazia ^{[1
]}

Carbotti, Grazia ^{[2
]}

Cuzzola, Angela ^{[3
]}

Fabbi, Marina ^{[2
]}

Ferrini, Silvano ^{[2
]}

Kohnke, Franz H. ^{[1
]}

Papanikolaou, Georgia ^{[1
]}

Plutino, Maria Rosaria ^{[4
]}

Rosano, Camillo ^{[2
]}

White, Andrew J. P. ^{[5
]}

机构：

[1] Univ Messina, Dipartimento Sci Chim, I-98166 Messina, Italy

[2] Ist Nazl Ric Canc, IRCCS AOU San Martino IST, I-16132 Genoa, Italy

[3] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy

[4] Univ Messina, Ist Studio Mat Nanostrutturati, ISMN CNR, OU Palermo,Dipartimento Sci Chim, I-98166 Messina, Italy

[5] Univ London Imperial Coll Sci Technol & Med, Chem Crystallog Lab, Dept Chem, London SW7 2AZ, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 07期

关键词：

TRANS-PLATINUM COMPLEXES; ANION-BINDING PROPERTIES; ANTICANCER DRUGS; CANCER-CHEMOTHERAPY; THERAPY; CALIXPYRROLES; CISPLATIN; CYTOTOXICITY; DENDRIMERS; RECEPTORS;

D O I：

10.1021/ja307791j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A meso-p-nitroaniline-calix[4]pyrrole derivative trans-coordinated to a Pt(II) center was synthesized and its structure solved by X-ray analysis. Adenosine monophosphate (AMP) was used as a model compound to evaluate the potential for the assisted delivery of the metal to the DNA nucleobases via the phosphate anion-binding properties of the calix[4]pyrrole unit. An NMR investigation of the kinetics of AMP complexation in the absence of an H-bonding competing solvent (dry CD3CN) was consistent with this hypothesis, but we could not detect the interaction of the calix[4]pyrrole with phosphate in the presence of water. However, in vitro tests of the new trans-calixpyrrole- Pt(II) complex on different cancer cell lines indicate a cytotoxic activity that is unquestionably derived from the coexistence of both the trans-Pt(II) fragment and the calix[4]pyrrole unit.

引用

页码：2544 / 2551

页数：8

共 53 条

[51] Host-Guest Chemistry of Dendrimer-Drug Complexes. 6. Fully Acetylated Dendrimers as Biocompatible Drug Vehicles Using Dexamethasone 21-Phosphate as a Model Drug [J].

Yang, Kun ;

Weng, Liang ;

Cheng, Yiyun ;

Zhang, Hongfeng ;

Zhang, Jiahai ;

Wu, Qinglin ;

Xu, Tongwen .

JOURNAL OF PHYSICAL CHEMISTRY B, 2011, 115 (10) :2185-2195

[52] New redox anion receptors based on calix[4]pyrrole bearing ferrocene amide [J].

Yang, Wenzhi ;

Yin, Zhenming ;

Wang, Chun-Hua ;

Huang, Chengyun ;

He, Jiaqi ;

Zhu, Xiaoqing ;

Cheng, Jin-Pei .

TETRAHEDRON, 2008, 64 (39) :9244-9252

[53] Effects of solvents on in vitro potencies of platinum compounds [J].

Yi, Yong Weon ;

Bae, Insoo .

DNA REPAIR, 2011, 10 (11) :1084-1085

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