Relevance of Magnetic Resonance Imaging for Early Detection and Diagnosis of Alzheimer Disease

被引：144

作者：

Teipel, Stefan J. ^{[1
,2
]}

Grothe, Michel ^{[2
]}

Lista, Simone ^{[3
]}

Toschi, Nicola ^{[4
]}

Garaci, Francesco G. ^{[5
,6
]}

Hampel, Harald ^{[3
]}

机构：

[1] Univ Med Rostock, Rostock, Germany

[2] German Ctr Neurodegenerat Dis, DZNE, Rostock, Germany

[3] Goethe Univ Frankfurt, Dept Psychiat, D-60054 Frankfurt, Germany

[4] Univ Roma Tor Vergata, Med Phys Sect, Fac Med, I-00133 Rome, Italy

[5] Univ Roma Tor Vergata, Dept Diagnost Imaging & Intervent Radiol, I-00133 Rome, Italy

[6] Inst Res & Med Care IRCCS San Raffaele, Rome, Italy

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2013年 / 97卷 / 03期

关键词：

Alzheimer disease; Preclinical diagnosis; Magnetic resonance imaging; Functional magnetic resonance imaging; Diffusion tensor imaging; Diffusion spectrum imaging; Multimodal imaging; Prediction; MILD COGNITIVE IMPAIRMENT; VOXEL-BASED MORPHOMETRY; MEDIAL TEMPORAL-LOBE; DIFFUSION-TENSOR MRI; MATTER MICROSTRUCTURAL CHANGES; FRACTAL-DIMENSION ANALYSIS; BASAL FOREBRAIN ATROPHY; FIBER TRACT INTEGRITY; DEFAULT-MODE NETWORK; NORMAL OLDER-ADULTS;

D O I：

10.1016/j.mcna.2012.12.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Magnetic resonance imaging (MRI)-based indicators of regional and global brain atrophy and more advanced measures of cortical functional and structural connectivity are among the most promising imaging biomarkers for the characterization of preclinical and prodromal stages of Alzheimer disease (AD). This review presents the current status of available and evolving MRI-based technologies for the early asymptomatic and predementia diagnosis of AD, including high-resolution structural MRI of global and regional brain atrophy, diffusion tensor imaging of structural cortical connectivity, and functional MRI during rest and task performance. The selection of an appropriate technique needs to consider its suitability for specific applications.

引用

页码：399 / +

页数：27

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