FABP5 as a possible biomarker in atopic march: FABP5-induced Th17 polarization, both in mouse model and human samples

被引：21

作者：

Lee, Jungsoo ^{[1
,2
,3
,4
]}

Kim, Bomi ^{[1
,2
]}

Chu, Howard ^{[1
,2
]}

Zhang, KeLun ^{[1
,2
,5
]}

Kim, Hyeran ^{[1
,2
]}

Kim, Ji Hye ^{[1
,2
,5
]}

Kim, Seo Hyeong ^{[1
,2
,5
]}

Pan, Youdong ^{[4
,6
]}

Noh, Ji Yeon ^{[1
,2
]}

Sun, ZhengWang ^{[1
,2
]}

Lee, Jongsun ^{[8
,9
]}

Jeong, Kyoung Yong ^{[8
,9
]}

Park, Kyung Hee ^{[8
,9
]}

Park, Jung-Won ^{[8
,9
]}

Kupper, Thomas S. ^{[7
]}

Park, Chang Ook ^{[1
,2
,5
,9
,10
]}

Lee, Kwang Hoon ^{[1
,2
,5
,9
,10
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Dermatol, Yonsei Ro 50-1, Seoul 03722, South Korea

[2] Yonsei Univ, Coll Med, Cutaneous Biol Res Inst, Yonsei Ro 50-1, Seoul 03722, South Korea

[3] Pusan Natl Univ, Yangsan Hosp, Dept Dermatol, Yangsan, South Korea

[4] Res Inst Convergence Biomed Sci & Technol, Yangsan, South Korea

[5] Yonsei Univ, Coll Med, Brain Korea 21 Project Med Sci, Seoul, South Korea

[6] Harvard Med Sch, Brigham & Womens Hosp, Dept Dermatol, Boston, MA 02115 USA

[7] Harvard Med Sch, Brigham & Womens Hosp, Harvard Skin Dis Res Ctr, Boston, MA 02115 USA

[8] Yonsei Univ, Coll Med, Dept Internal Med, Div Allergy & Immunol, Seoul, South Korea

[9] Yonsei Univ, Coll Med, Inst Allergy, Seoul, South Korea

[10] Yonsei Univ, Coll Med, Inst Allergy, Seoul, South Korea

来源：

EBIOMEDICINE | 2020年 / 58卷

基金：

新加坡国家研究基金会;

关键词：

Atopic dermatitis; Atopic march; Fatty-acid-binding protein 5; IL-17A; Th17; ACID-BINDING PROTEIN; MEMORY T-CELLS; AIRWAY INFLAMMATION; DERMATITIS; CHILDREN; DIFFERENTIATION; MECHANISMS; FEATURES; RISK; ACTIVATION;

D O I：

10.1016/j.ebiom.2020.102879

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: While the incidence of patients with atopic dermatitis (AD) with atopic march (AM) showing respiratory allergy is steadily rising, the pathomechanism is still unknown. There are currently no biomarkers to predict progression of AM. Methods: To explore the mechanism of AM, patients with AD and AM and healthy controls were recruited and RNA microarray, flow cytometry, quantitative real-time polymerase chain reaction, and immunofluorescence staining were performed. We also co-cultured dendritic cells and CD4(+) T cells with various Dermatophagoides farinae allergen fractions. Cytokine levels were evaluated using enzyme-linked immunosorbent assay. Findings: Both fatty-acid-binding protein 5 (FABP5) and Th17-related genes were more highly expressed in AM. FABP5 knockdown significantly decreased Th17-inducing cytokines in keratinocytes and IL-17A in T cells from AM patients. Further confirmation was obtained using an AM mice model compared to mice without AM. Der f 1, a major D. farinae allergen, increased FABP5 and IL-17A expression in T cells from AM patients. Higher serum FABP5 levels from AM patients were positively correlated with serum IL-17A levels. Interpretation: FABP5 expression, possibly enhanced by higher epicutaneous and respiratory sensitization to Der f 1, may directly promote Th17 responses in AD patients with AM. Thus, AM progression can be explained by Th17 reaction induced by FABP5. FABP5 was identified as a potential biomarker in AM. (c) 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/)

引用

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