Chitosan-hydroxycinnamic acid conjugates: Preparation, antioxidant and antimicrobial activity

被引：138
|
作者：
Lee, Dae-Sung [1 ]
Woo, Ji-Young [2 ]
Ahn, Chang-Bum [3 ]
Je, Jae-Young [2 ]
机构：
[1] POSTECH, POSTECH Ocean Sci & Technol Inst, Pohang 790784, South Korea
[2] Chonnam Natl Univ, Dept Marine Biofood Sci, Yeosu 550749, South Korea
[3] Chonnam Natl Univ, Div Food & Nutr, Kwangju 5507757, South Korea
来源：
FOOD CHEMISTRY | 2014年 / 148卷
基金：
新加坡国家研究基金会;
关键词：
Chitosan; Hydroxycinnamic acid; Antioxidant; Antimicrobial; Cytocompatibility; RELEVANCE; EXTRACT;
D O I：
10.1016/j.foodchem.2013.10.019
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In this study, the antioxidant and antimicrobial activities of chitosan-caffeic acid, chitosan-ferulic acid, and chitosan-sinapic acid conjugates with different grafting ratios were investigated. The synthesized chitosan-hydroxycinnamic acid conjugates were verified by performing H-1 NMR and differential scanning calorimetry analysis. The antioxidant activities of the conjugates were increased compared to the unmodified chitosan, by 1.79-fold to 5.05-fold (2,2-diphenyl-1-picrylhydrazyl scavenging assay), 2.44-fold to 4.12-fold (hydrogen peroxide scavenging assay), 1.34-fold to 3.35-fold (ABTS radical scavenging assay), and also exhibited an increased reducing power. The conjugates also showed excellent lipid peroxidation inhibition abilities in a linoleic acid emulsion system. The conjugates exhibited antimicrobial activity against 15 clinical isolates, two standard methicillin-resistant Staphylococcus aureus (MRSA) and three standard methicillin-susceptible S. aureus strains, as well as eight foodborne pathogens. Additionally, the conjugates showed no cytotoxic activity towards human Chang liver and mouse macrophage RAW264.7 cells. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：97 / 104
页数：8
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