SLC9/NHE gene family, a plasma membrane and organellar family of Na+/H+ exchangers

被引：206
作者：
Donowitz, Mark [1 ,2 ]
Tse, C. Ming [1 ,2 ]
Fuster, Daniel [3 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21205 USA
[3] Univ Hosp Bern, GNI Inst Biochem & Mol Med, Dept Hypertens & Nephrol, Bern, Switzerland
来源：
MOLECULAR ASPECTS OF MEDICINE | 2013年 / 34卷 / 2-3期
基金：
美国国家卫生研究院; 瑞士国家科学基金会;
关键词：
SLC9; Na/H exchanger gene family; Antiporter; 1:1 stoichiometry; Na absorption; Intracellular pH; INTESTINAL NHE8 EXPRESSION; LINKED MENTAL-RETARDATION; PROTEIN-KINASE-C; TARGETED DISRUPTION; BRUSH-BORDER; DIFFERENTIAL REGULATION; EVOLUTIONARY ORIGINS; PH REGULATION; ISOFORM; SODIUM;
D O I：
10.1016/j.mam.2012.05.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This brief review of the human Na/H exchanger gene family introduces a new classification with three subgroups to the SLC9 gene family. Progress in the structure and function of this gene family is reviewed with structure based on homology to the bacterial Na/H exchanger NhaA. Human diseases which result from genetic abnormalities of the SLC9 family are discussed although the exact role of these transporters in causing any disease is not established, other than poorly functioning NHE3 in congenital Na diarrhea (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：236 / 251
页数：16
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