Embedding of Active Proteins and Living Cells in Redox-Sensitive Hydrogels and Nanogels through Enzymatic Cross-Linking

被引：90

作者：

Singh, Smriti ^{[1
,2
]}

Topuz, Fuat ^{[1
,2
]}

Hahn, Kathrin ^{[3
]}

Albrecht, Krystyna ^{[3
]}

Groll, Juergen ^{[3
]}

机构：

[1] Rhein Westfal TH Aachen, DWI eV, D-52056 Aachen, Germany

[2] Rhein Westfal TH Aachen, Inst Tech & Macromol Chem, D-52056 Aachen, Germany

[3] Univ Wurzburg, Dept & Chair Funct Mat Med & Dent, D-97070 Wurzburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 10期

关键词：

colloids; enzyme catalysis; gels; horseradish peroxidase (HRP); redox-sensitive materials; INVERSE MINIEMULSION; DRUG-DELIVERY; PEROXIDE; ACID; OXIDATION; SITE;

D O I：

10.1002/anie.201206266

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Horseradish peroxidase (HRP) can be used for the enzymatic cross-linking of thiol-functionalized polymers under mild conditions to form hydrogels and nanogels without the need for added H2O2. Cells can be embedded in the hydrogels and proteins can be entrapped and released from the nanogels. These gels are fully degradable under mild and cytocompatible reductive conditions. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3000 / 3003

页数：4

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