Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4

被引：156

作者：

Xu, Jianfeng ^{[2
,3
,4
,5
]}

Mo, Zengnan ^{[6
,7
]}

Ye, Dingwei ^{[8
,9
]}

Wang, Meilin ^{[10
,11
]}

Liu, Fang ^{[2
,3
]}

Jin, Guangfu ^{[5
,11
,12
,13
]}

Xu, Chuanliang ^{[1
]}

Wang, Xiang ^{[2
]}

Shao, Qiang ^{[14
]}

Chen, Zhiwen ^{[15
]}

Tao, Zhihua ^{[16
]}

Qi, Jun ^{[17
]}

Zhou, Fangjian ^{[18
,19
]}

Wang, Zhong ^{[5
,20
]}

Fu, Yaowen ^{[21
]}

He, Dalin ^{[22
]}

Wei, Qiang ^{[23
]}

Guo, Jianming ^{[24
]}

Wu, Denglong ^{[25
]}

Gao, Xin ^{[26
]}

Yuan, Jianlin ^{[27
]}

Wang, Gongxian ^{[28
]}

Xu, Yong ^{[29
]}

Wang, Guozeng ^{[30
]}

Yao, Haijun ^{[20
]}

Dong, Pei ^{[18
,19
]}

Jiao, Yang ^{[17
]}

Shen, Mo ^{[31
]}

Yang, Jin ^{[32
]}

Jun Ou-Yang ^{[33
]}

Jiang, Haowen ^{[2
]}

Zhu, Yao ^{[8
,9
]}

Ren, Shancheng ^{[1
]}

Zhang, Zhengdong ^{[10
,11
]}

Yin, Changjun ^{[34
]}

Gao, Xu ^{[1
]}

Dai, Bo ^{[8
,9
]}

Hu, Zhibin ^{[11
,12
,13
]}

Yang, Yajun ^{[35
,36
,37
]}

Wu, Qijun ^{[38
]}

Chen, Hongyan ^{[3
,4
]}

Peng, Peng ^{[39
]}

Zheng, Ying ^{[39
]}

Zheng, Xiaodong ^{[40
,41
,42
]}

Xiang, Yongbing ^{[43
]}

Long, Jirong ^{[44
]}

Gong, Jian ^{[2
]}

Na, Rong ^{[2
]}

Lin, Xiaoling ^{[2
,3
]}

Yu, Hongjie ^{[3
,4
]}

机构：

[1] Second Mil Med Univ, Shanghai Changhai Hosp, Dept Urol, Shanghai, Peoples R China

[2] Fudan Univ, Huashan Hosp, Fudan Inst Urol, Shanghai 200433, Peoples R China

[3] Fudan Univ, Sch Life Sci, Fudan Ctr Genet Epidemiol, Shanghai 200433, Peoples R China

[4] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

[5] Wake Forest Univ, Bowman Gray Sch Med, Ctr Canc Genom, Winston Salem, NC USA

[6] Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning, Peoples R China

[7] Guangxi Med Univ, Affiliated Hosp 1, Dept Urol & Nephrol, Nanning, Peoples R China

[8] Fudan Univ, Shanghai Med Coll, Shanghai Canc Ctr, Dept Urol, Shanghai 200433, Peoples R China

[9] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200433, Peoples R China

[10] Nanjing Med Univ, Sch Publ Hlth, Minist Educ, Dept Mol & Genet Toxicol,Key Lab Modern Toxicol, Nanjing, Jiangsu, Peoples R China

[11] Nanjing Med Univ, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China

[12] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China

[13] Nanjing Med Univ, Ctr Canc, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing, Jiangsu, Peoples R China

[14] Suzhou Municipal Hosp, Dept Urol, Suzhou, Peoples R China

[15] Third Mil Med Univ, Southwest Hosp, Urol Inst Peoples Liberat Army PLA, Chongqing, Peoples R China

[16] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Lab Med, Hangzhou 310003, Zhejiang, Peoples R China

[17] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Urol, Shanghai 200030, Peoples R China

[18] State Key Lab Oncol So China, Guangzhou, Guangdong, Peoples R China

[19] Sun Yat Sen Univ, Ctr Canc, Dept Urol, Guangzhou 510275, Guangdong, Peoples R China

[20] Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Urol, Shanghai 200030, Peoples R China

[21] Jilin Univ, Hosp 1, Dept Urol, Changchun 130023, Peoples R China

[22] Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Urol, Xian 710049, Peoples R China

[23] Sichuan Univ, W China Hosp, Dept Urol, Chengdu 610064, Peoples R China

[24] Fudan Univ, Zhongshan Hosp, Dept Urol, Shanghai 200433, Peoples R China

[25] Tongji Univ, Tongji Hosp, Dept Urol, Shanghai 200092, Peoples R China

[26] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Urol, Guangzhou 510275, Guangdong, Peoples R China

[27] Fourth Mil Med Univ, Xijing Hosp, Dept Urol, Xian 710032, Peoples R China

[28] Nanchang Univ, Affiliated Hosp 1, Dept Urol, Nanchang, Jiangxi, Peoples R China

[29] TianJin Med Univ, TianJin Inst Urol, Hosp 2, Dept Urol, Tianjin, Peoples R China

[30] Pudong Gongli Hosp, Dept Urol, Shanghai, Peoples R China

[31] Wenzhou Med Coll, Affiliated Hosp 1, Dept Lab Med, Wenzhou, Peoples R China

[32] Third Mil Med Univ, Dept Cell Biol, Chongqing, Peoples R China

[33] Suzhou Univ, Peoples Hosp 1, Dept Urol, Suzhou 215006, Peoples R China

[34] Nanjing Med Univ, Affiliated Hosp 1, Dept Urol, Nanjing, Jiangsu, Peoples R China

[35] Fudan Univ, Minist Educ, Key Lab Contemporary Anthropol, Sch Life Sci, Shanghai 200433, Peoples R China

[36] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China

[37] Fudan Taizhou Inst Hlth Sci, Taizhou, Peoples R China

[38] Shanghai Jiao Tong Univ, Shanghai Canc Inst, Renji Hosp, State Key Lab Oncogene & Related Genes,Sch Med, Shanghai 200030, Peoples R China

[39] Shanghai Municipal Ctr Dis Control & Prevent, Dept Canc Prevent & Control, Shanghai, Peoples R China

[40] Anhui Med Univ, Hosp 1, Inst Dermatol, Hefei, Peoples R China

[41] Anhui Med Univ, Hosp 1, Dept Dermatol, Hefei, Peoples R China

[42] Minist Natl Sci & Technol, State Key Lab Incubat Base Dermatol, Hefei, Peoples R China

[43] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China

[44] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Med,Vanderbilt Epidemiol Ctr,Div Epidemiol, Nashville, TN 37212 USA

[45] Canc Prevent Inst Calif, Fremont, CA USA

[46] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[47] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[48] Shanghai Jiao Tong Univ, Sch Publ Hlth, Shanghai 200030, Peoples R China

来源：

NATURE GENETICS | 2012年 / 44卷 / 11期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

SUSCEPTIBILITY LOCUS; GENE-CLUSTER; CLASS-I; VARIANTS; RECEPTORS;

D O I：

10.1038/ng.2424

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Prostate cancer risk-associated variants have been reported in populations of European descent, African-Americans and Japanese using genome-wide association studies (GWAS). To systematically investigate prostate cancer risk-associated variants in Chinese men, we performed the first GWAS in Han Chinese. In addition to confirming several associations reported in other ancestry groups, this study identified two new risk-associated loci for prostate cancer on chromosomes 9q31.2 (rs817826, P = 5.45 x 10(-14)) and 19q13.4 (rs103294, P = 5.34 x 10(-16)) in 4,484 prostate cancer cases and 8,934 controls. The rs103294 marker at 19q13.4 is in strong linkage equilibrium with a 6.7-kb germline deletion that removes the first six of seven exons in LILRA3, a gene regulating inflammatory response, and was significantly associated with the mRNA expression of LILRA3 in T cells (P < 1 x 10(-4)). These findings may advance the understanding of genetic susceptibility to prostate cancer.

引用

页码：1231 / 1235

页数：5

共 27 条

[1] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese [J].

Akamatsu, Shusuke ;

Takata, Ryo ;

Haiman, Christopher A. ;

Takahashi, Atsushi ;

Inoue, Takahiro ;

Kubo, Michiaki ;

Furihata, Mutsuo ;

Kamatani, Naoyuki ;

Inazawa, Johji ;

Chen, Gary K. ;

Le Marchand, Loic ;

Kolonel, Laurence N. ;

Katoh, Takahiko ;

Yamano, Yuko ;

Yamakado, Minoru ;

Takahashi, Hiroyuki ;

Yamada, Hiroki ;

Egawa, Shin ;

Fujioka, Tomoaki ;

Henderson, Brian E. ;

Habuchi, Tomonori ;

Ogawa, Osamu ;

Nakamura, Yusuke ;

Nakagawa, Hidewaki .

NATURE GENETICS, 2012, 44 (04) :426-U234

[2] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[3]

Borges L, 1997, J IMMUNOL, V159, P5192

[4] Inflammation in prostate carcinogenesis [J].

De Marzo, Angelo M. ;

Platz, Elizabeth A. ;

Sutcliffe, Siobhan ;

Xu, Jianfeng ;

Gronberg, Henrik ;

Drake, Charles G. ;

Nakai, Yasutomo ;

Isaacs, William B. ;

Nelson, William G. .

NATURE REVIEWS CANCER, 2007, 7 (04) :256-269

[5] Common Regulatory Variation Impacts Gene Expression in a Cell Type-Dependent Manner [J].

Dimas, Antigone S. ;

Deutsch, Samuel ;

Stranger, Barbara E. ;

Montgomery, Stephen B. ;

Borel, Christelle ;

Attar-Cohen, Homa ;

Ingle, Catherine ;

Beazley, Claude ;

Arcelus, Maria Gutierrez ;

Sekowska, Magdalena ;

Gagnebin, Marilyne ;

Nisbett, James ;

Deloukas, Panos ;

Dermitzakis, Emmanouil T. ;

Antonarakis, Stylianos E. .

SCIENCE, 2009, 325 (5945) :1246-1250

[6] Multiple newly identified loci associated with prostate cancer susceptibility [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

[7] Identification of seven new prostate cancer susceptibility loci through a genome-wide association study [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Al Olama, Ali Amin ;

Giles, Graham G. ;

Guy, Michelle ;

Severi, Gianluca ;

Muir, Kenneth ;

Hopper, John L. ;

Henderson, Brian E. ;

Haiman, Christopher A. ;

Schleutker, Johanna ;

Hamdy, Freddie C. ;

Neal, David E. ;

Donovan, Jenny L. ;

Stanford, Janet L. ;

Ostrander, Elaine A. ;

Ingles, Sue A. ;

John, Esther M. ;

Thibodeau, Stephen N. ;

Schaid, Daniel ;

Park, Jong Y. ;

Spurdle, Amanda ;

Clements, Judith ;

Dickinson, Joanne L. ;

Maier, Christiane ;

Vogel, Walther ;

Doerk, Thilo ;

Rebbeck, Timothy R. ;

Cooney, Kathleen A. ;

Cannon-Albright, Lisa ;

Chappuis, Pierre O. ;

Hutter, Pierre ;

Zeegers, Maurice ;

Kaneva, Radka ;

Zhang, Hong-Wei ;

Lu, Yong-Jie ;

Foulkes, William D. ;

English, Dallas R. ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Morrison, Jonathan ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Wilkinson, Rosemary A. ;

Saunders, Edward J. ;

Page, Elizabeth C. ;

Sawyer, Emma J. ;

Edwards, Stephen M. ;

Dearnaley, David P. .

NATURE GENETICS, 2009, 41 (10) :1116-U97

[8] Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Manolescu, Andrei ;

Gudbjartsson, Daniel ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Blondal, Thorarinn ;

Jakobsdottir, Margret ;

Stacey, Simon N. ;

Kostic, Jelena ;

Kristinsson, Kari T. ;

Birgisdottir, Birgitta ;

Ghosh, Shyamali ;

Magnusdottir, Droplaug N. ;

Thorlacius, Steinunn ;

Thorleifsson, Gudmar ;

Zheng, S. Lilly ;

Sun, Jielin ;

Chang, Bao-Li ;

Elmore, J. Bradford ;

Breyer, Joan P. ;

McReynolds, Kate M. ;

Bradley, Kevin M. ;

Yaspan, Brian L. ;

Wiklund, Fredrik ;

Stattin, Par ;

Lindstrom, Sara ;

Adami, Hans-Olov ;

McDonnell, Shannon K. ;

Schaid, Daniel J. ;

Cunningham, Julie M. ;

Wang, Liang ;

Cerhan, James R. ;

St Sauver, Jennifer L. ;

Isaacs, Sara D. ;

Wiley, Kathleen E. ;

Partin, Alan W. ;

Walsh, Patrick C. ;

Polo, Sonia ;

Ruiz-Echarri, Manuel ;

Navarrete, Sebastian ;

Fuertes, Fernando ;

Saez, Berta ;

Godino, Javier ;

Weijerman, Philip C. ;

Swinkels, Dorine W. ;

Aben, Katja K. .

NATURE GENETICS, 2008, 40 (03) :281-283

[9] Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Steinthorsdottir, Valgerdur ;

Bergthorsson, Jon T. ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Rafnar, Thorunn ;

Gudbjartsson, Daniel ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Blondal, Thorarinn ;

Stacey, Simon N. ;

Helgason, Agnar ;

Gunnarsdottir, Steinunn ;

Olafsdottir, Adalheidur ;

Kristinsson, Kari T. ;

Birgisdottir, Birgitta ;

Ghosh, Shyamali ;

Thorlacius, Steinunn ;

Magnusdottir, Dana ;

Stefansdottir, Gerdur ;

Kristjansson, Kristleifur ;

Bagger, Yu ;

Wilensky, Robert L. ;

Reilly, Muredach P. ;

Morris, Andrew D. ;

Kimber, Charlotte H. ;

Adeyemo, Adebowale ;

Chen, Yuanxiu ;

Zhou, Jie ;

So, Wing-Yee ;

Tong, Peter C. Y. ;

Ng, Maggie C. Y. ;

Hansen, Torben ;

Andersen, Gitte ;

Borch-Johnsen, Knut ;

Jorgensen, Torben ;

Tres, Alejandro ;

Fuertes, Fernando ;

Ruiz-Echarri, Manuel ;

Asin, Laura ;

Saez, Berta ;

van Boven, Erica ;

Klaver, Siem ;

Swinkels, Dorine W. ;

Aben, Katja K. ;

Graif, Theresa .

NATURE GENETICS, 2007, 39 (08) :977-983

[10] Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Manolescu, Andrei ;

Amundadottir, Laufey T. ;

Gudbjartsson, Daniel ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Xu, Jianfeng ;

Blondal, Thorarinn ;

Kostic, Jelena ;

Sun, Jielin ;

Ghosh, Shyamali ;

Stacey, Simon N. ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Kristjansson, Kristleifur ;

Tres, Alejandro ;

Partin, Alan W. ;

Albers-Akkers, Marjo T. ;

Marcos, Javier Godino-Ivan ;

Walsh, Patrick C. ;

Swinkels, Dorine W. ;

Navarrete, Sebastian ;

Isaacs, Sarah D. ;

Aben, Katja K. ;

Graif, Theresa ;

Cashy, John ;

Ruiz-Echarri, Manuel ;

Wiley, Kathleen E. ;

Suarez, Brian K. ;

Witjes, J. Alfred ;

Frigge, Mike ;

Ober, Carole ;

Jonsson, Eirikur ;

Einarsson, Gudmundur V. ;

Mayordomo, Jose I. ;

Kiemeney, Lambertus A. ;

Isaacs, William B. ;

Catalona, William J. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Thorsteinsdottir, Unnur ;

Kong, Augustine .

NATURE GENETICS, 2007, 39 (05) :631-637

← 1 2 3 →

共 27 条

[1] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese [J].

Akamatsu, Shusuke ;

Takata, Ryo ;

Haiman, Christopher A. ;

Takahashi, Atsushi ;

Inoue, Takahiro ;

Kubo, Michiaki ;

Furihata, Mutsuo ;

Kamatani, Naoyuki ;

Inazawa, Johji ;

Chen, Gary K. ;

Le Marchand, Loic ;

Kolonel, Laurence N. ;

Katoh, Takahiko ;

Yamano, Yuko ;

Yamakado, Minoru ;

Takahashi, Hiroyuki ;

Yamada, Hiroki ;

Egawa, Shin ;

Fujioka, Tomoaki ;

Henderson, Brian E. ;

Habuchi, Tomonori ;

Ogawa, Osamu ;

Nakamura, Yusuke ;

Nakagawa, Hidewaki .

NATURE GENETICS, 2012, 44 (04) :426-U234

[2] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[3]

Borges L, 1997, J IMMUNOL, V159, P5192

[4] Inflammation in prostate carcinogenesis [J].

De Marzo, Angelo M. ;

Platz, Elizabeth A. ;

Sutcliffe, Siobhan ;

Xu, Jianfeng ;

Gronberg, Henrik ;

Drake, Charles G. ;

Nakai, Yasutomo ;

Isaacs, William B. ;

Nelson, William G. .

NATURE REVIEWS CANCER, 2007, 7 (04) :256-269

[5] Common Regulatory Variation Impacts Gene Expression in a Cell Type-Dependent Manner [J].

Dimas, Antigone S. ;

Deutsch, Samuel ;

Stranger, Barbara E. ;

Montgomery, Stephen B. ;

Borel, Christelle ;

Attar-Cohen, Homa ;

Ingle, Catherine ;

Beazley, Claude ;

Arcelus, Maria Gutierrez ;

Sekowska, Magdalena ;

Gagnebin, Marilyne ;

Nisbett, James ;

Deloukas, Panos ;

Dermitzakis, Emmanouil T. ;

Antonarakis, Stylianos E. .

SCIENCE, 2009, 325 (5945) :1246-1250

[6] Multiple newly identified loci associated with prostate cancer susceptibility [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

[7] Identification of seven new prostate cancer susceptibility loci through a genome-wide association study [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Al Olama, Ali Amin ;

Giles, Graham G. ;

Guy, Michelle ;

Severi, Gianluca ;

Muir, Kenneth ;

Hopper, John L. ;

Henderson, Brian E. ;

Haiman, Christopher A. ;

Schleutker, Johanna ;

Hamdy, Freddie C. ;

Neal, David E. ;

Donovan, Jenny L. ;

Stanford, Janet L. ;

Ostrander, Elaine A. ;

Ingles, Sue A. ;

John, Esther M. ;

Thibodeau, Stephen N. ;

Schaid, Daniel ;

Park, Jong Y. ;

Spurdle, Amanda ;

Clements, Judith ;

Dickinson, Joanne L. ;

Maier, Christiane ;

Vogel, Walther ;

Doerk, Thilo ;

Rebbeck, Timothy R. ;

Cooney, Kathleen A. ;

Cannon-Albright, Lisa ;

Chappuis, Pierre O. ;

Hutter, Pierre ;

Zeegers, Maurice ;

Kaneva, Radka ;

Zhang, Hong-Wei ;

Lu, Yong-Jie ;

Foulkes, William D. ;

English, Dallas R. ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Morrison, Jonathan ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Wilkinson, Rosemary A. ;

Saunders, Edward J. ;

Page, Elizabeth C. ;

Sawyer, Emma J. ;

Edwards, Stephen M. ;

Dearnaley, David P. .

NATURE GENETICS, 2009, 41 (10) :1116-U97

[8] Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Manolescu, Andrei ;

Gudbjartsson, Daniel ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Blondal, Thorarinn ;

Jakobsdottir, Margret ;

Stacey, Simon N. ;

Kostic, Jelena ;

Kristinsson, Kari T. ;

Birgisdottir, Birgitta ;

Ghosh, Shyamali ;

Magnusdottir, Droplaug N. ;

Thorlacius, Steinunn ;

Thorleifsson, Gudmar ;

Zheng, S. Lilly ;

Sun, Jielin ;

Chang, Bao-Li ;

Elmore, J. Bradford ;

Breyer, Joan P. ;

McReynolds, Kate M. ;

Bradley, Kevin M. ;

Yaspan, Brian L. ;

Wiklund, Fredrik ;

Stattin, Par ;

Lindstrom, Sara ;

Adami, Hans-Olov ;

McDonnell, Shannon K. ;

Schaid, Daniel J. ;

Cunningham, Julie M. ;

Wang, Liang ;

Cerhan, James R. ;

St Sauver, Jennifer L. ;

Isaacs, Sara D. ;

Wiley, Kathleen E. ;

Partin, Alan W. ;

Walsh, Patrick C. ;

Polo, Sonia ;

Ruiz-Echarri, Manuel ;

Navarrete, Sebastian ;

Fuertes, Fernando ;

Saez, Berta ;

Godino, Javier ;

Weijerman, Philip C. ;

Swinkels, Dorine W. ;

Aben, Katja K. .

NATURE GENETICS, 2008, 40 (03) :281-283

[9] Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Steinthorsdottir, Valgerdur ;

Bergthorsson, Jon T. ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Rafnar, Thorunn ;

Gudbjartsson, Daniel ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Blondal, Thorarinn ;

Stacey, Simon N. ;

Helgason, Agnar ;

Gunnarsdottir, Steinunn ;

Olafsdottir, Adalheidur ;

Kristinsson, Kari T. ;

Birgisdottir, Birgitta ;

Ghosh, Shyamali ;

Thorlacius, Steinunn ;

Magnusdottir, Dana ;

Stefansdottir, Gerdur ;

Kristjansson, Kristleifur ;

Bagger, Yu ;

Wilensky, Robert L. ;

Reilly, Muredach P. ;

Morris, Andrew D. ;

Kimber, Charlotte H. ;

Adeyemo, Adebowale ;

Chen, Yuanxiu ;

Zhou, Jie ;

So, Wing-Yee ;

Tong, Peter C. Y. ;

Ng, Maggie C. Y. ;

Hansen, Torben ;

Andersen, Gitte ;

Borch-Johnsen, Knut ;

Jorgensen, Torben ;

Tres, Alejandro ;

Fuertes, Fernando ;

Ruiz-Echarri, Manuel ;

Asin, Laura ;

Saez, Berta ;

van Boven, Erica ;

Klaver, Siem ;

Swinkels, Dorine W. ;

Aben, Katja K. ;

Graif, Theresa .

NATURE GENETICS, 2007, 39 (08) :977-983

[10] Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Manolescu, Andrei ;

Amundadottir, Laufey T. ;

Gudbjartsson, Daniel ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Bergthorsson, Jon T. ;

Agnarsson, Bjarni A. ;

Baker, Adam ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Jakobsdottir, Margret ;

Xu, Jianfeng ;

Blondal, Thorarinn ;

Kostic, Jelena ;

Sun, Jielin ;

Ghosh, Shyamali ;

Stacey, Simon N. ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Kristjansson, Kristleifur ;

Tres, Alejandro ;

Partin, Alan W. ;

Albers-Akkers, Marjo T. ;

Marcos, Javier Godino-Ivan ;

Walsh, Patrick C. ;

Swinkels, Dorine W. ;

Navarrete, Sebastian ;

Isaacs, Sarah D. ;

Aben, Katja K. ;

Graif, Theresa ;

Cashy, John ;

Ruiz-Echarri, Manuel ;

Wiley, Kathleen E. ;

Suarez, Brian K. ;

Witjes, J. Alfred ;

Frigge, Mike ;

Ober, Carole ;

Jonsson, Eirikur ;

Einarsson, Gudmundur V. ;

Mayordomo, Jose I. ;

Kiemeney, Lambertus A. ;

Isaacs, William B. ;

Catalona, William J. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Thorsteinsdottir, Unnur ;

Kong, Augustine .

NATURE GENETICS, 2007, 39 (05) :631-637

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