Electrochemical oxidation of the hypoglycaemic drug gliclazide

被引：27

作者：

Radi, A ^{[1
]}

El Ries, MA

Bekhiet, GE

机构：

[1] Mansoura Univ, Fac Sci, Dept Chem, Demiatta 34517, Egypt

[2] Natl Org Drug Control & Res, Cairo, Egypt

来源：

ANALYTICAL LETTERS | 1999年 / 32卷 / 08期

关键词：

gliclazide; cyclic voltammetry; differential pulse voltammetry;

D O I：

10.1080/00032719908542919

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The electrochemical oxidation of gliclazide has been studied in Britton-Robinson buffers in the pH range of 2.0-12.0 by cyclic voltammetry and differential pulse polarography at carbon paste electrode. Gliclazide gave rise to two voltammetric peaks, corresponding to the oxidation of hydrazide -CO-NH-NR2 moiety (where R-2 are cycloalkylamino ring). The oxidation process has been shown to be irreversible and diffusion-controlled with adsorption characteristics over the entire pH range. Analytical methods with adequate precision and accuracy have been developed for the voltammetric determination of gliclazide in tablets.

引用

页码：1603 / 1612

页数：10

共 10 条

[1]

*AMA, 1992, DRUG EV ANN 1992, P953

[2]

BROWN ER, 1971, TECHNIQUES CHEM, P476

[3]

El-Kousy N., 1990, J DRUG RES, V19, P35

[4] Controlled potential oxidation of some arylhydrazides [J].

Hazard, R ;

LeFloch, M ;

Tallec, A .

ELECTROCHIMICA ACTA, 1996, 41 (18) :2871-2875

[5]

HEYROVSKY M, 1972, J ELECTROANAL CHEM, V36, P203, DOI 10.1016/S0022-0728(72)80459-5

[6] UTILITY OF CERTAIN PI-ACCEPTORS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF GLICLAZIDE AND TOLAZAMIDE [J].

HUSSEIN, SA ;

MOHAMED, AMI ;

ABDELALIM, AAM .

ANALYST, 1989, 114 (09) :1129-1131

[7]

KISSINGER PT, 1984, LAB TECHNIQUES ELECT, P37

[8]

KOBAYASHI K, 1986, CHEM PHARM BULL, V34, P2957

[9]

TRAVIS RH, 1970, PHARMACOL BASIS, P1581

[10]

1985, REMINGTON PHARM SCI, P977

← 1 →