A highly selective turn-on near-infrared fluorescent probe for hydrogen sulfide detection and imaging in living cells

被引：256

作者：

Wang, Rui ^{[1
]}

Yu, Fabiao ^{[1
]}

Chen, Lingxin ^{[1
]}

Chen, Hao ^{[1
]}

Wang, Linjie ^{[1
]}

Zhang, Weiwei ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 96期

基金：

中国国家自然科学基金;

关键词：

H2S; REDUCTION; PERFUSION;

D O I：

10.1039/c2cc36088h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have described a turn-on near-infrared fluorescent probe Cy-NO2 based on nitro group reduction for intracellular H2S detection. The probe employs cyanine dye as a fluorophore, and is equipped with a nitro group as a fluorescent modulator. It is readily employed for assessing intracellular H2S level changes, and confocal imaging is achieved successfully.

引用

页码：11757 / 11759

页数：3

共 29 条

[1]

Abe K, 1996, J NEUROSCI, V16, P1066

[2] Quantifying Colocalization by Correlation: The Pearson Correlation Coefficient is Superior to the Mander's Overlap Coefficient [J].

Adler, Jeremy ;

Parmryd, Ingela .

CYTOMETRY PART A, 2010, 77A (08) :733-742

[3] Measurement of reduced sulphur compounds contained in aqueous matrices by direct injection into a gas chromatograph with a flame photometric detector [J].

Bérubé, PR ;

Parkinson, PD ;

Hall, ER .

JOURNAL OF CHROMATOGRAPHY A, 1999, 830 (02) :485-489

[4] Sulfide-selective chemosignaling by a Cu2+ complex of dipicolylamine appended fluorescein [J].

Choi, Myung Gil ;

Cha, Sunyoung ;

Lee, Haekyung ;

Jeon, Hye Lim ;

Chang, Suk-Kyu .

CHEMICAL COMMUNICATIONS, 2009, (47) :7390-7392

[5] New roles for cysteine and transsulfuration enzymes:: Production of H2S, a neuromodulator and smooth muscle relaxant [J].

Dominy, JE ;

Stipanuk, MH .

NUTRITION REVIEWS, 2004, 62 (09) :348-353

[6] RETRACTED: Brain hydrogen sulfide is severely decreased in Alzheimer's disease (Retracted Article) [J].

Eto, K ;

Asada, T ;

Arima, K ;

Makifuchi, T ;

Kimura, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 293 (05) :1485-1488

[7] The third gas:: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis [J].

Fiorucci, S ;

Antonelli, E ;

Mencarelli, A ;

Orlandi, S ;

Renga, B ;

Rizzo, G ;

Distrutti, E ;

Shah, V ;

Morelli, A .

HEPATOLOGY, 2005, 42 (03) :539-548

[8] Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values [J].

Furne, Julie ;

Saeed, Aalia ;

Levitt, Michael D. .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2008, 295 (05) :R1479-R1485

[9] Hydrogen sulfide and carbon monoxide are in synergy with each other in the pathogenesis of recurrent febrile seizures [J].

Han, Y ;

Qin, J ;

Chang, XZ ;

Yang, ZX ;

Du, JB .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 2006, 26 (01) :101-107

[10] Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria [J].

Hildebrandt, Tatjana M. ;

Grieshaber, Manfred K. .

FEBS JOURNAL, 2008, 275 (13) :3352-3361

← 1 2 3 →