Role of AgRP on Ghrelin-induced feeding in the hypothalamic paraventricular nucleus

被引：13

作者：

Shrestha, YB ^{[1
]}

Wickwire, K ^{[1
]}

Giraudo, SQ ^{[1
]}

机构：

[1] Univ Georgia, Dept Food & Nutr, Athens, GA 30602 USA

来源：

REGULATORY PEPTIDES | 2006年 / 133卷 / 1-3期

关键词：

agouti-related protein (AgRP); paraventricular nucleus of the hypothalamus (PVN); ghrelin; food intake;

D O I：

10.1016/j.regpep.2005.09.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MT II, agonist for MC3/4-Rs, inhibited Ghrelin's orexigenic effect in the paraventricular nucleus of the hypothalamus (PVN). To further investigate the role of the melanocortin system as mediator of ghrelin's orexigenic actions, we explored the involvement of AgRP in Ghrelin's orexigenic effect by testing the effect on food intake after their co-administration in the PVN, during the light and dark phases of feeding in rats. During both the phases of feeding, co-administration of Ghrelin with either AgRP 50 or AgRP 100 pmol into the PVN did not produce a synergistic effect on the food intake, suggesting that ghrelin induction of feeding occurs by recruiting Agrp as one of the obligatory mediators of its orexigenic effect. (c) 2005 Elsevier B.V. All rights reserved.

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收藏

页码：68 / 73

页数：6

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