In vitro and in vivo Antitumor Activity of Doxorubicin-Loaded Alginic-Acid-Based Nanoparticles

被引：17
作者：
Cheng, Yuan [1 ,2 ]
Yu, Shuling [1 ,2 ]
Wang, Jingjing [1 ,2 ]
Qian, Hanqing [1 ,2 ]
Wu, Wei [1 ,2 ]
Jiang, Xiqun [1 ,2 ]
机构：
[1] Nanjing Univ, Lab Mesoscop Chem, Nanjing 210093, Jiangsu, Peoples R China
[2] Nanjing Univ, Dept Polymer Sci & Engn, Coll Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China
来源：
MACROMOLECULAR BIOSCIENCE | 2012年 / 12卷 / 10期
关键词：
alginic acid; antitumor; drug delivery; nanoparticles; self-assembly; DRUG-DELIVERY; BIODEGRADABLE NANOPARTICLES; ENHANCED PERMEABILITY; GOLD NANOPARTICLES; RETENTION EPR; TUMOR; CHITOSAN; MICELLES; RELEASE; CARRIER;
D O I：
10.1002/mabi.201200165
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The antitumor activities of DOX-loaded alginic acid/poly[2-(diethylamino)ethyl methacrylate] (ALG-PDEA) nanoparticles are evaluated both in vitro and in vivo. TEM imaging shows that the ALG-PDEA NPs have a spherical morphology with a size of about 120?nm. CLSM observations reveal that the negatively charged ALG-PDEA NPs can be taken up well by cells. In vivo NIR fluorescence imaging shows that the ALG-PDEA NPs can passively target the tumor area because of the EPR effect in the H22 tumor-bearing mouse. In vivo antitumor efficacy examinations indicate that DOX-loaded ALG-PDEA NPs have significantly superior efficacy in impeding tumor growth compared to free DOX and low toxicity to living mice.
引用
收藏
页码：1326 / 1335
页数：10
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