Inhaled corticosteroids for the treatment of COVID-19

被引：12

作者：

Bafadhel, Mona ^{[1
]}

Faner, Rosa ^{[2
]}

Taille, Camille ^{[3
]}

Russell, Richard E. K. ^{[1
]}

Welte, Tobias ^{[4
]}

Barnes, Peter J. ^{[5
]}

Agusti, Alvar ^{[6
,7
]}

机构：

[1] Kings Coll London, Fac Life Sci & Med, Kings Ctr Lung Hlth, Sch Immunol & Microbial Sci, London, England

[2] IDIBAPS, CIBER Enfermedades Resp, Barcelona, Spain

[3] Univ Paris, Univ Hosp Bichat Claude Bernard, AP HP Nord, Dept Pulm Dis, Paris, France

[4] Hannover Univ, Dept Pulm & Infect Dis, Sch Med, Hannover, Germany

[5] Imperial Coll London, Natl Heart & Lung Inst, London, England

[6] Univ Barcelona, Hosp Clin Barcelona, Resp Inst, Catedra Salud Resp,IDIBAPS, Barcelona, Spain

[7] CIBERES, Barcelona, Spain

来源：

EUROPEAN RESPIRATORY REVIEW | 2022年 / 31卷 / 166期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; ASTHMA EXACERBATIONS; RESPIRATORY VIRUSES; COMORBID ASTHMA; CORONAVIRUS; OUTCOMES; RISK; BUDESONIDE; EOSINOPHILIA; COMBINATION;

D O I：

10.1183/16000617.0099-2022

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused severe illness and mortality for millions worldwide. Despite the development, approval and rollout of vaccination programmes globally to prevent infection by SARS-CoV-2 and the development of coronavirus disease 2019 (COVID-19), treatments are still urgently needed to improve outcomes. Early in the pandemic it was observed that patients with pre-existing asthma or COPD were underrepresented among those with COVID-19. Evidence from clinical studies indicates that the inhaled corticosteroids (ICS) routinely taken for asthma and COPD could have had a protective role in preventing severe COVID-19 and, therefore, may be a promising treatment for COVID-19. This review summarises the evidence supporting the beneficial effects of ICS on outcomes in patients with COVID-19 and explores the potential protective mechanisms.

引用

页数：13

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