The role of Trim25 in development, disease and RNA metabolism

被引：48

作者：

Heikel, Gregory ^{[1
]}

Choudhury, Nila Roy ^{[1
]}

Michlewski, Gracjan ^{[1
]}

机构：

[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Michael Swann Bldg, Edinburgh EH9 3BF, Midlothian, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2016年 / 44卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

E3 ubiquitin ligase; novel RNA-binding proteins; RNA metabolism; Trim25; RESPONSIVE FINGER PROTEIN; UBIQUITIN LIGASE EFP; ESTROGEN-RECEPTOR-ALPHA; EMBRYONIC STEM-CELLS; RIG-I; MESSENGER-RNA; BREAST-CANCER; POSTTRANSCRIPTIONAL REGULATION; CAENORHABDITIS-ELEGANS; BINDING PROTEINS;

D O I：

10.1042/BST20160077

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trim25 is a member of the tripartite motif family of E3 ubiquitin ligases. It plays major roles in innate immunity and defence against viral infection, control of cell proliferation and migration of cancer cells. Recent work identified Trim25 as being able to bind to RNA and to regulate Lin28a-mediated uridylation of pre-let-7. Here we review the current knowledge of the role of Trim25 in development, disease and RNA metabolism.

引用

页码：1045 / 1050

页数：6

共 51 条

[1] The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts [J].

Baltz, Alexander G. ;

Munschauer, Mathias ;

Schwanhaeusser, Bjoern ;

Vasile, Alexandra ;

Murakawa, Yasuhiro ;

Schueler, Markus ;

Youngs, Noah ;

Penfold-Brown, Duncan ;

Drew, Kevin ;

Milek, Miha ;

Wyler, Emanuel ;

Bonneau, Richard ;

Selbach, Matthias ;

Dieterich, Christoph ;

Landthaler, Markus .

MOLECULAR CELL, 2012, 46 (05) :674-690

[2] The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs [J].

Beckmann, Benedikt M. ;

Horos, Rastislav ;

Fischer, Bernd ;

Castello, Alfredo ;

Eichelbaum, Katrin ;

Alleaume, Anne-Marie ;

Schwarzl, Thomas ;

Curk, Tomaz ;

Foehr, Sophia ;

Huber, Wolfgang ;

Krijgsveld, Jeroen ;

Hentze, Matthias W. .

NATURE COMMUNICATIONS, 2015, 6

[3] RNA-binding E3 ubiquitin ligases: novel nucleic acid regulation [J].

Cano, Florencia ;

Saavedra, Diego Miranda ;

Lehner, Paul J. .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2010, 38 :1621-1626

[4] Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins [J].

Castello, Alfredo ;

Fischer, Bernd ;

Eichelbaum, Katrin ;

Horos, Rastislav ;

Beckmann, Benedikt M. ;

Strein, Claudia ;

Davey, Norman E. ;

Humphreys, David T. ;

Preiss, Thomas ;

Steinmetz, Lars M. ;

Krijgsveld, Jeroen ;

Hentze, Matthias W. .

CELL, 2012, 149 (06) :1393-1406

[5] A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway [J].

Chang, Hao-Ming ;

Triboulet, Robinson ;

Thornton, James E. ;

Gregory, Richard I. .

NATURE, 2013, 497 (7448) :244-+

[6] Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation [J].

Choudhury, Nila Roy ;

Nowak, Jakub S. ;

Zuo, Juan ;

Rappsilber, Juri ;

Spoel, Steven H. ;

Michlewski, Gracjan .

CELL REPORTS, 2014, 9 (04) :1265-1272

[7] RBPDB: a database of RNA-binding specificities [J].

Cook, Kate B. ;

Kazan, Hilal ;

Zuberi, Khalid ;

Morris, Quaid ;

Hughes, Timothy R. .

NUCLEIC ACIDS RESEARCH, 2011, 39 :D301-D308

[8] Regulation of the vascular endothelial growth factor and growth by estrogen and antiestrogens through Efp in Ishikawa endometrial carcinoma cells [J].

Dai, Hongying ;

Zhang, Ping ;

Zhao, Shuping ;

Zhang, Jingjing ;

Wang, Bo .

ONCOLOGY REPORTS, 2009, 21 (02) :395-401

[9] A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice [J].

Donelan, NR ;

Basler, CF ;

García-Sastre, A .

JOURNAL OF VIROLOGY, 2003, 77 (24) :13257-13266

[10] Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP [J].

Dong, Xue-Yuan ;

Fu, Xiaoying ;

Fan, Songqing ;

Guo, Peng ;

Su, Dan ;

Dong, Jin-Tang .

BIOCHEMICAL JOURNAL, 2012, 444 :581-590

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