The role of Trim25 in development, disease and RNA metabolism

被引：44
作者：
Heikel, Gregory [1 ]
Choudhury, Nila Roy [1 ]
Michlewski, Gracjan [1 ]
机构：
[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Michael Swann Bldg, Edinburgh EH9 3BF, Midlothian, Scotland
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2016年 / 44卷
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
E3 ubiquitin ligase; novel RNA-binding proteins; RNA metabolism; Trim25; RESPONSIVE FINGER PROTEIN; UBIQUITIN LIGASE EFP; ESTROGEN-RECEPTOR-ALPHA; EMBRYONIC STEM-CELLS; RIG-I; MESSENGER-RNA; BREAST-CANCER; POSTTRANSCRIPTIONAL REGULATION; CAENORHABDITIS-ELEGANS; BINDING PROTEINS;
D O I：
10.1042/BST20160077
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Trim25 is a member of the tripartite motif family of E3 ubiquitin ligases. It plays major roles in innate immunity and defence against viral infection, control of cell proliferation and migration of cancer cells. Recent work identified Trim25 as being able to bind to RNA and to regulate Lin28a-mediated uridylation of pre-let-7. Here we review the current knowledge of the role of Trim25 in development, disease and RNA metabolism.
引用
收藏
页码：1045 / 1050
页数：6
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