A DIStinctively novel exoribonuclease that really likes U

被引：12

作者：

Gallouzi, Imed E. ^{[1
]}

Wilusz, Jeffrey ^{[2
]}

机构：

[1] McGill Univ, Dept Biochem, Rosalind & Morris Goodman Canc Ctr, Montreal, PQ, Canada

[2] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

来源：

EMBO JOURNAL | 2013年 / 32卷 / 13期

关键词：

MESSENGER-RNA DECAY; PERLMAN SYNDROME; PATHWAY; DIS3L2;

D O I：

10.1038/emboj.2013.136

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulated degradation plays a major role in determining the levels of both non-coding (miRNA) and coding (mRNA) transcripts. Thus, insights into the factors and pathways that influence this process have broad, interdisciplinary implications. New findings by Malecki et al (2013), Lubas et al (2013), and Chang et al (2013) identify the protein Dis3L2 as a major player in the 3'-5' exonucleolytic decay of transcripts. Furthermore, they demonstrate a strong connection between terminal uridylation of the RNA substrate and enzymatic activity.

引用

页码：1799 / 1801

页数：3

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