The autophagic network and cancer

被引：246

作者：

Rybstein, Marissa D. ^{[1
]}

Bravo-San Pedro, Jose Manuel ^{[2
,3
,4
,5
,6
]}

Kroemer, Guido ^{[2
,3
,4
,5
,6
,7
,8
]}

Galluzzi, Lorenzo ^{[1
,2
,9
]}

机构：

[1] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY 10065 USA

[2] Univ Paris Descartes Paris V, Paris, France

[3] Univ Pierre & Marie Curie Paris VI, Paris, France

[4] Ctr Rech Cordeliers, Equipe Labellisee Ligue Canc 11, Paris, France

[5] INSERM, U1138, Paris, France

[6] Gustave Roussy Comprehens Canc Inst, Metabol & Cell Biol Platforms, Villejuif, France

[7] Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France

[8] Karolinska Univ Hosp, Dept Womens & Childrens Hlth, Stockholm, Sweden

[9] Sandra & Edward Meyer Canc Ctr, New York, NY 10021 USA

来源：

NATURE CELL BIOLOGY | 2018年 / 20卷 / 03期

基金：

欧洲研究理事会;

关键词：

CELLS REQUIRE AUTOPHAGY; DRIVES TUMOR-GROWTH; INHIBITS AUTOPHAGY; HMGB1; EXPRESSION; SUPPRESSOR-CELLS; LC3B PUNCTA; TUMORIGENESIS; PROMOTES; SURVIVAL; METABOLISM;

D O I：

10.1038/s41556-018-0042-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism and cope with microenvironmental perturbations. Moreover, autophagy connects cellular adaptation with extracellular circuitries that impinge on immunity and metabolism. As it links transformed and non-transformed components of the tumour microenvironment, such an autophagic network is important for cancer initiation, progression and response to therapy. Here, we discuss the mechanisms whereby the autophagic network interfaces with multiple aspects of malignant disease.

引用

页码：243 / 251

页数：9

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