Enantioselective dearomatization of isoquinolines by anion-binding catalysis en route to cyclic α-aminophosphonates

被引：74

作者：

Choudhury, Abhijnan Ray ^{[1
]}

Mukherjee, Santanu ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

CHEMICAL SCIENCE | 2016年 / 7卷 / 12期

关键词：

PHOSPHONIC ACID-DERIVATIVES; HETEROBIMETALLIC LANTHANOID COMPLEXES; BOND-FORMING REACTIONS; C-H FUNCTIONALIZATION; ASYMMETRIC-SYNTHESIS; AMINO PHOSPHONATES; STEREOSELECTIVE-SYNTHESIS; ISOTHIOCYANATO PHOSPHONATES; ANTIBACTERIAL AGENTS; ABRAMOV REACTION;

D O I：

10.1039/c6sc02466a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantioselective dearomatization of isoquinolines has been developed using chiral anion-binding catalysis. This transformation, catalyzed by a simple and easy to prepare tert-leucine-based thiourea derivative, makes use of silyl phosphite as a nucleophile and generates cyclic alpha-aminophosphonates. This is the first time asymmetric anion-binding catalysis has been applied to the synthesis of alpha-aminophosphonates.

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收藏

页码：6940 / 6945

页数：6

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