Novel Cationic Quinazolin-4(3H)-one Conjugated Fullerene Nanoparticles as Antimycobacterial and Antimicrobial Agents

被引：23
作者：
Patel, Manishkumar B. [1 ]
Harikrishnan, Uma [1 ]
Valand, Nikunj N. [1 ]
Modi, Nishith R. [1 ]
Menon, Shobhana K. [1 ]
机构：
[1] Gujarat Univ, Sch Sci, Dept Chem, Ahmadabad 380009, Gujarat, India
来源：
ARCHIV DER PHARMAZIE | 2013年 / 346卷 / 03期
关键词：
Antibacterial study; Antifungal study; Antimycobacterial study; Cationic fulleropyrrolidines; Quinazolin-4(3H)-one; BIOLOGICAL EVALUATION; C-60; DERIVATIVES; MYCOBACTERIA; DESIGN; DRUG;
D O I：
10.1002/ardp.201200371
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel cationic fullerene derivatives bearing a substituted-quinazolin-4(3H)-one moiety as a side arm were synthesized using the 1,3-dipolar cycloaddition reaction of C60 with azomethine ylides generated from the corresponding Schiff bases of substituted quinazolinones. The synthesized compounds 5af were characterized by elemental analysis, FT-IR, 1H NMR, 13C NMR, and ESI-MS and screened for their antibacterial activity against Mycobacterium tuberculosis (H37RV) and antimicrobial activity against selected Gram-positive (Staphylococcus aureus and S. pyogenes) and Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumonia and Escherichia coli) bacterial and fungal strains (Candida albicans, Aspergillus clavatus, and A. niger), respectively. All the compounds exhibited significant activity, with the most effective compounds having MIC values and zones of inhibition comparable to those of standard drugs.
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收藏
页码：210 / 220
页数：11
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