Diversity of energy metabolism in immune responses regulated by micro-organisms and dietary nutrition

被引：27

作者：

Hosomi, Koji ^{[1
,2
]}

Kunisawa, Jun ^{[1
,2
,3
,4
,5
]}

机构：

[1] Natl Inst Biomed Innovat Hlth & Nutr NIBIOHN, Lab Vaccine Mat, Ctr Vaccine & Adjuvant Res, 7-6-8 Saito Asagi, Ibaraki, Osaka 5670085, Japan

[2] Natl Inst Biomed Innovat Hlth & Nutr NIBIOHN, Lab Gut Environm Syst, 7-6-8 Saito Asagi, Ibaraki, Osaka 5670085, Japan

[3] Univ Tokyo, Int Res & Dev Ctr Mucosal Vaccines, Inst Med Sci, Minato Ku, 4-6-1 Shiroganedai, Tokyo 1080071, Japan

[4] Osaka Univ, Grad Sch Med, Grad Sch Pharmaceut Sci, Grad Sch Dens, 1-1 Yamadaoka, Suita, Osaka 5650871, Japan

[5] Kobe Univ, Grad Sch Med, Tyuou Ku, 7-5-1 Kusunokityou, Kobe, Hyogo 6500017, Japan

来源：

INTERNATIONAL IMMUNOLOGY | 2020年 / 32卷 / 07期

基金：

日本学术振兴会;

关键词：

fatty acid; host defense; metabolite; symbiotic bacteria; vitamin B1; CONJUGATED LINOLEIC-ACID; T-CELL-ACTIVATION; SPHINGOSINE; 1-PHOSPHATE; B-LYMPHOCYTES; LYMPHOID-TISSUES; CUTTING EDGE; DIFFERENTIATION; KINASE; MTOR; INFLAMMATION;

D O I：

10.1093/intimm/dxaa020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune metabolism has been recognized as a new paradigm in the regulation of host immunity. In the environment, there are many micro-organisms including pathogenic and non-pathogenic and/or beneficial ones. Immune cells exhibit various responses against different types of microbes, which seem to be associated with changes in energy metabolism. In addition, dietary nutrition influences host metabolism and consequent responses by immune cells. In this review, we describe the complex network of immune metabolism from the perspectives of nutrition, micro-organisms and host immunity for the control of immunologic health and diseases.

引用

页码：447 / 454

页数：8

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