In vitro survival and germination of Candida albicans in the presence of nitrogen compounds

被引：14

作者：

Abaitua, F ^{[1
]}

Rementería, A ^{[1
]}

San Millan, R ^{[1
]}

Eguzkiza, A ^{[1
]}

Rodriguez, JA ^{[1
]}

Pontón, J ^{[1
]}

Sevilla, MJ ^{[1
]}

机构：

[1] Univ Basque Country, Dept Microbiol Inmunol & Parasitol, E-48080 Bilbao, Spain

来源：

MICROBIOLOGY-SGM | 1999年 / 145卷

关键词：

nitric oxide; sodium nitroprusside; candidacidal activity; dimorphism; Candida albicans;

D O I：

10.1099/13500872-145-7-1641

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro effect of nitric oxide (NO) and nitrite on blastoconidia and hyphae of Candida albicans was studied. Sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) were used as NO donors. Both minimal and complex media at two pH values, 7.0 and 4.5, were used for the assays. Blastoconidia were more susceptible than hyphae to NO. The NO effect on blastoconidia was greater at acidic ph. Nitrite affected the viability of blastoconidia in complex medium. The percentage germination and the relative rate of elongation of hyphae were both enhanced when NO was present in acidic conditions.

引用

页码：1641 / 1647

页数：7

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