Gleaning relapse risk from B cell phenotype: decreased CD5+ B cells portend a shorter time to relapse after B cell depletion in patients with ANCA-associated vasculitis

被引：21

作者：

Bunch, Donna O. ^{[1
]}

Mendoza, Carmen E. ^{[1
]}

Aybar, Lydia T. ^{[1
]}

Kotzen, Elizabeth S. ^{[1
]}

Colby, Kerry R. ^{[1
]}

Hu, Yichun ^{[1
]}

Hogan, Susan L. ^{[1
]}

Poulton, Caroline J. ^{[1
]}

Schmitz, John L. ^{[2
]}

Falk, Ronald J. ^{[1
]}

Nachman, Patrick H. ^{[1
]}

Pendergraft, William F. ^{[1
]}

McGregor, JulieAnne G. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Med, Kidney Ctr, Chapel Hill, NC USA

[2] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2015年 / 74卷 / 09期

关键词：

MAINTENANCE THERAPY; RITUXIMAB; CYCLOPHOSPHAMIDE; INDUCTION;

D O I：

10.1136/annrheumdis-2014-206756

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：1784 / U201

页数：3

共 10 条

[1] Reduced CD5+CD24hiCD38hi and interleukin-10+ regulatory B cells in active anti-neutrophil cytoplasmic autoantibody-associated vasculitis permit increased circulating autoantibodies [J].

Aybar, L. T. ;

McGregor, J. G. ;

Hogan, S. L. ;

Hu, Y. ;

Mendoza, C. E. ;

Brant, E. J. ;

Poulton, C. J. ;

Henderson, C. D. ;

Falk, R. J. ;

Bunch, D. O. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2015, 180 (02) :178-188

[2] Decreased CD5+ B Cells in Active ANCA Vasculitis and Relapse after Rituximab [J].

Bunch, Donna O'Dell ;

McGregor, JulieAnne G. ;

Khandoobhai, Nirmal B. ;

Aybar, Lydia T. ;

Burkart, Madelyn E. ;

Hu, Yichun ;

Hogan, Susan L. ;

Poulton, Caroline J. ;

Berg, Elisabeth A. ;

Falk, Ronald J. ;

Nachman, Patrick H. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2013, 8 (03) :382-391

[3] Rituximab for induction and maintenance therapy in granulomatosis with polyangiitis (Wegener's). Results of a single-center cohort study on 66 patients [J].

Calich, Ana Luisa ;

Puechal, Xavier ;

Pugnet, Gregory ;

London, Jonathan ;

Terrier, Benjamin ;

Charles, Pierre ;

Mouthon, Luc ;

Guillevin, Loic .

JOURNAL OF AUTOIMMUNITY, 2014, 50 :135-141

[4] Human CD5 promotes B-cell survival through stimulation of autocrine IL-10 production [J].

Gary-Gouy, H ;

Harriague, J ;

Bismuth, G ;

Platzer, C ;

Schmitt, C ;

Dalloul, AH .

BLOOD, 2002, 100 (13) :4537-4543

[5] Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis. [J].

Jones, Rachel B. ;

Tervaert, Jan Willem Cohen ;

Hauser, Thomas ;

Luqmani, Raashid ;

Morgan, Matthew D. ;

Peh, Chen Au ;

Savage, Caroline O. ;

Segelmark, Marten ;

Tesar, Vladimir ;

van Paassen, Pieter ;

Walsh, Dorothy ;

Walsh, Michael ;

Westman, Kerstin ;

Jayne, David R. W. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (03) :211-220

[6] Rituximab for the Treatment of Relapses in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis [J].

Miloslavsky, E. M. ;

Specks, U. ;

Merkel, P. A. ;

Seo, P. ;

Spiera, R. ;

Langford, C. A. ;

Hoffman, G. S. ;

Kallenberg, C. G. M. ;

Clair, E. W. St. ;

Tchao, N. K. ;

Viviano, L. ;

Ding, L. ;

Ikle, D. ;

Villarreal, M. ;

Jepson, B. ;

Brunetta, P. ;

Allen, N. B. ;

Fervenza, F. C. ;

Geetha, D. ;

Keogh, K. ;

Kissin, E. Y. ;

Monach, P. A. ;

Peikert, T. ;

Stegeman, C. ;

Ytterberg, S. R. ;

Stone, J. H. .

ARTHRITIS & RHEUMATOLOGY, 2014, 66 (11) :3151-3159

[7] Long-Term Maintenance Therapy Using Rituximab-Induced Continuous B-Cell Depletion in Patients with ANCA Vasculitis [J].

Pendergraft, William F., III ;

Cortazar, Frank B. ;

Wenger, Julia ;

Murphy, Andrew P. ;

Rhee, Eugene P. ;

Laliberte, Karen A. ;

Niles, John L. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2014, 9 (04) :736-744

[8] Use of CD45 gating in three and four-color flow cytometric immunophenotyping: Guideline from the national institute of allergy and infectious diseases, division of AIDS [J].

Schnizlein-Bick, CT ;

Mandy, FF ;

O'Gorman, MRG ;

Paxton, H ;

Nicholson, JKA ;

Hultin, LE ;

Gelman, RS ;

Wilkening, CL ;

Livnat, D .

CYTOMETRY, 2002, 50 (02) :46-52

[9] Efficacy of Remission-Induction Regimens for ANCA-Associated Vasculitis [J].

Specks, Ulrich ;

Merkel, Peter A. ;

Seo, Philip ;

Spiera, Robert ;

Langford, Carol A. ;

Hoffman, Gary S. ;

Kallenberg, Cees G. M. ;

Clair, E. William St. ;

Fessler, Barri J. ;

Ding, Linna ;

Viviano, Lisa ;

Tchao, Nadia K. ;

Phippard, Deborah J. ;

Asare, Adam L. ;

Lim, Noha ;

Ikle, David ;

Jepson, Brett ;

Brunetta, Paul ;

Allen, Nancy B. ;

Fervenza, Fernando C. ;

Geetha, Duvuru ;

Keogh, Karina ;

Kissin, Eugene Y. ;

Monach, Paul A. ;

Peikert, Tobias ;

Stegeman, Coen ;

Ytterberg, Steven R. ;

Mueller, Mark ;

Sejismundo, Lourdes P. ;

Mieras, Kathleen ;

Stone, John H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (05) :417-427

[10] Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis. [J].

Stone, John H. ;