Improving hyperglycemic effect of FGF-21 is associated with alleviating inflammatory state in diabetes

被引：21

作者：

Wang, Nan ^{[1
]}

Xu, Tong-yu ^{[2
]}

Zhang, Xu ^{[1
]}

Li, Jun-yan ^{[1
]}

Wang, Yun-xin ^{[1
]}

Guo, Xiao-chen ^{[1
]}

Li, Si-ming ^{[3
]}

Wang, Wen-fei ^{[1
,4
]}

Li, De-shan ^{[1
,4
]}

机构：

[1] Northeast Agr Univ, Life Sci Coll, Biopharmaceut Lab, Harbin 150030, Heilongjiang, Peoples R China

[2] Heilongjiang Inst Food & Drug Control, Harbin 150088, Heilongjiang, Peoples R China

[3] Harbin Univ Commerce, Harbin, Heilongjiang, Peoples R China

[4] Northeast Agr Univ, Key Lab Agr Biol Funct Gene, Harbin 150030, Heilongjiang, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2018年 / 56卷

关键词：

FGF-21; Inflammation; Glucose uptake; 3T3-L1; adipocytes; NF-kappa B; GROWTH-FACTOR; 21; C-REACTIVE PROTEIN; METABOLIC SYNDROME; INSULIN-RESISTANCE; PANCREATIC-ISLETS; ADIPOSE-TISSUE; GLUCOSE; INTERLEUKIN-6; FGF21; ACTIVATION;

D O I：

10.1016/j.intimp.2018.01.048

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type 2 diabetes mellitus (T2DM) is accompanied by abnormal glucose metabolism and low-grade chronic inflammation. Fibroblast growth factor 21 (FGF-21) is a novel metabolic regulator and can function as an endocrine hormone to regulate glucose and lipid metabolism. Recently, FGF-21 was found to have anti-inflammatory effect, to our knowledge, the effect of FGF-21 on inflammatory state in diabetes has not been elucidated. Here, we use db/db mice as a Type 2 diabetes model to determine whether FGF-21 alleviates inflammatory state while improves hyperglycemia. Our results demonstrated that FGF-21 not only showed potent long lasting hypoglycemic effect, but also demonstrated strong anti-inflammatory effect in the serum and white adipose tissue. Besides, in vitro experiments, insulin resistance (IR) was induced in 3T3-L1 adipocytes by treating with TNF-alpha. Our results showed that TNF-alpha impaired glucose metabolism of 3T3-L1 adipocytes but FGF-21 repressed gene expression of inflammatory factors caused by IR and consequently improved the glucose metabolism in 3T3-L1 adipocytes. Furthermore, FGF-21 ameliorated glucose uptake of TNF-alpha-induced IR in 3T3-L1 adipocytes by inhibiting NF-kappa B signaling pathway.

引用

页码：301 / 309

页数：9

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