Mapping Long-Term Functional Changes in Cerebral Blood Flow by Arterial Spin Labeling

被引：14

作者：

Ssali, Tracy ^{[1
,2
]}

Anazodo, Udunna C. ^{[1
,2
]}

Bureau, Yves ^{[1
]}

MacIntosh, Bradley J. ^{[3
]}

Guenther, Matthias ^{[4
,5
]}

St Lawrence, Keith ^{[1
,2
]}

机构：

[1] Lawson Hlth Res Inst, London, ON, Canada

[2] Western Univ, Dept Med Biophys, London, ON, Canada

[3] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

[4] Fraunhofer Inst Med Image Comp MEVIS, Bremen, Germany

[5] Mediri GmbH, Heidelberg, Germany

来源：

PLOS ONE | 2016年 / 11卷 / 10期

基金：

加拿大健康研究院;

关键词：

PERFUSION MRI; FMRI DATA; REPRODUCIBILITY; RELIABILITY; BRAIN; ACTIVATION; TASK; TIME; 3T; NORMALIZATION;

D O I：

10.1371/journal.pone.0164112

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although arterial spin labeling (ASL) is appealing for mapping long-term changes in functional activity, inter-sessional variations in basal blood flow, arterial transit times (ATTs), and alignment errors, can result in significant false activation when comparing images from separate sessions. By taking steps to reduce these sources of noise, this study assessed the ability of ASL to detect functional CBF changes between sessions. ASL data were collected in three sessions to image ATT, resting CBF and CBF changes associated with motor activation (7 participants). Activation maps were generated using rest and task images acquired in the same session and from sessions separated by up to a month. Good agreement was found when comparing between-session activation maps to within-session activation maps with only a 16% decrease in precision (within-session: 90 +/- 7%) and a 13% decrease in the Dice similarity (within-session: 0.75 +/- 0.07) coefficient after a month. In addition, voxel-wise reproducibility (within-session: 4.7 +/- 4.5%) and reliability (within-session: 0.89 +/- 0.20) of resting grey-matter CBF decreased by less than 18% for the between-session analysis relative to within-session values. ATT variability between sessions (5.0 +/- 2.7%) was roughly half the between-subject variability, indicating that its effects on longitudinal CBF were minimal. These results demonstrate that conducting voxel-wise analysis on CBF images acquired on different days is feasible with only modest loss in precision, highlighting the potential of ASL for longitudinal studies.

引用

页数：18