Intestinal Dysbiosis, Gut Hyperpermeability and Bacterial Translocation: Missing Links Between Depression, Obesity and Type 2 Diabetes?

被引：91

作者：

Slyepchenko, Anastasiya ^{[1
,2
]}

Maes, Michael ^{[3
,4
,5
,6
,7
]}

Machado-Vieira, Rodrigo ^{[8
,9
]}

Anderson, George ^{[10
]}

Solmi, Marco ^{[11
,12
,13
]}

Sanz, Yolanda ^{[14
]}

Berk, Michael ^{[4
,15
,16
]}

Kohler, Cristiano A. ^{[17
,18
]}

Carvalho, Andre F. ^{[17
,18
]}

机构：

[1] McMaster Univ, MiNDS, McMaster Integrat Neurosci Discovery & Study, Hamilton, ON, Canada

[2] St Josephs Healthcare Hamilton, Womens Hlth Concerns Clin, Hamilton, ON, Canada

[3] Chulalongkorn Univ, Dept Psychiat, Fac Med, Bangkok, Thailand

[4] Deakin Univ, IMPACT Res Ctr, Geelong, Vic, Australia

[5] Univ Estadual Londrina, Fac Med, Dept Psychiat, Londrina, Brazil

[6] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria

[7] Revitalis, Waalre, Netherlands

[8] Univ Sao Paulo, Lab Neurosci LIM 27, Dept & Inst Psychiat, Fac Med, BR-05508 Sao Paulo, Brazil

[9] NIMH, Expt Therapeut & Pathophysiol Branch, NIH, Bethesda, MD 20892 USA

[10] CRC Scotland & London, Eccleston Sq, London, England

[11] Univ Padua, Dept Neurosci, Padua, Italy

[12] Mental Hlth Dept, Local Hlth Unit 17, Padua, Italy

[13] IREM, Inst Clin Res & Educ Med, Padua, Italy

[14] Natl Res Council IATA CSIC, Microbial Ecol Nutr & Hlth Res Unit, Inst Agrochem & Food Technol, Av Agustin Escardino 7, Paterna Valencia 46980, Spain

[15] Univ Melbourne, Dept Psychiat, Florey Inst Neurosci & Mental Hlth, Ctr Youth Mental Hlth, Parkville, Vic, Australia

[16] Univ Melbourne, Orygen Natl Ctr Excellence Youth Mental Hlth, Ctr Youth Mental Hlth, Parkville, Vic, Australia

[17] Univ Fed Ceara, Dept Clin Med, Fac Med, Rua Prof Costa Mendes 1608,4 Andar, BR-60430040 Fortaleza, Ceara, Brazil

[18] Univ Fed Ceara, Translat Psychiat Res Grp, Fac Med, Fortaleza, Ceara, Brazil

来源：

CURRENT PHARMACEUTICAL DESIGN | 2016年 / 22卷 / 40期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Microbiome; gut; probiotics; type 2 diabetes mellitus; obesity; metabolic syndrome; major depressive disorder; psychiatry; NECROSIS-FACTOR-ALPHA; INCREASED OXIDATIVE STRESS; ANXIETY-LIKE BEHAVIOR; C-REACTIVE PROTEIN; CHAIN FATTY-ACIDS; LACTOBACILLUS-HELVETICUS R0052; BIFIDOBACTERIUM-LONGUM R0175; IMMUNO-INFLAMMATORY PATHWAYS; COMMON MENTAL-DISORDERS; PLASMA GHRELIN LEVELS;

D O I：

10.2174/1381612822666160922165706

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The comorbid prevalence of major depressive disorder (MDD) with obesity and type II diabetes mellitus reflects the existence of a subset of individuals with a complex common pathophysiology and overlapping risk factors. Such comorbid disease presentations imply a number of difficulties, including: decreased treatment responsivity and adherence; altered glycemic control and increased risk of wider medical complications. A number of factors link MDD to metabolic-associated disorders, including: higher rates of shared risk factors such as poor diet and physical inactivity and biological elements including increased inflammation; insulin resistance; oxidative and nitrosative stress; and mitochondrial dysfunction. All of these biological factors have been extensively investigated in the pathophysiology of obesity and type 2 diabetes mellitus as well as MDD. In this review, we aim to: (1) overview the epidemiological links between MDD, obesity and type 2 diabetes mellitus; (2) discuss the role of synergistic neurotoxic effects in MDD comorbid with obesity, and type 2 diabetes mellitus; (3) review evidence of intestinal dysbiosis, leaky gut and increased bacterial translocation, in the pathophysiology of MDD, obesity and type 2 diabetes mellitus; and (4) propose a model in which the gut-brain axis could play a pivotal role in the comorbidity of these disorders.

引用

页码：6087 / 6106

页数：20

共 329 条

[1] Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial [J].