The functions of microRNAs in pluripotency and reprogramming

被引：119

作者：

Leonardo, Trevor R. ^{[1
,2
]}

Schultheisz, Heather L. ^{[1
,2
]}

Loring, Jeanne F. ^{[1
,2
]}

Laurent, Louise C. ^{[3
]}

机构：

[1] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA

[2] Ctr Regenerat Med, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Dept Reprod Med, La Jolla, CA 92037 USA

来源：

NATURE CELL BIOLOGY | 2012年 / 14卷 / 11期

关键词：

EMBRYONIC STEM-CELLS; GENOME-WIDE IDENTIFICATION; INTEGRATED ANALYSIS MMIA; ADULT HUMAN FIBROBLASTS; RNA-BINDING PROTEIN; DNA METHYLATION; TRANSCRIPTIONAL REPRESSORS; MESENCHYMAL TRANSITION; MIR-200; FAMILY; SOMATIC-CELLS;

D O I：

10.1038/ncb2613

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pluripotent stem cells (PSCs) express a distinctive set of microRNAs (miRNAs). Many of these miRNAs have similar targeting sequences and are predicted to regulate downstream targets cooperatively. These enriched miRNAs are involved in the regulation of the unique PSC cell cycle, and there is increasing evidence that they also influence other important characteristics of PSCs, including their morphology, epigenetic profile and resistance to apoptosis. Detailed studies of miRNAs and their targets in PSCs should help to parse the regulatory networks that underlie developmental processes and cellular reprogramming.

引用

页码：1114 / 1121

页数：8

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