Synthesis and biological activity of novel sialyl-Lewis(X) conjugates

被引：11
作者：
Sprengard, U
Kunz, H
Huls, C
Schmidt, W
Seiffge, D
Kretzschmar, G
机构：
[1] HOECHST AG,ZENTFORSCH,D-65926 FRANKFURT,GERMANY
[2] HOECHST AG,PHARMA FORSCH,D-65174 WIESBADEN,GERMANY
[3] UNIV MAINZ,INST ORGAN CHEM,D-55099 MAINZ,GERMANY
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 05期
关键词：
D O I：
10.1016/0960-894X(96)00057-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel sialyl Lewis(x) conjugates have been synthesized and evaluated as inhibitors of E- and P-selectin mediated cell adhesion in cell culture assays. The most potent conjugate in the static inhibition assays exhibited a significant and dose-dependent pharmacological potency as inhibitor of the endotoxin-induced leukocyte adhesion to the endothelium of postcapillary venules in rats.
引用
收藏
页码：509 / 514
页数：6
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