Thermoresponsive sodium alginate-g-poly(N-isopropylacrylamide) copolymers III. Solution properties

被引：39
|
作者：
Cheaburu, Catalina Natalia [1 ]
Ciocoiu, Oana-Nicoleta [2 ,3 ]
Staikos, Georgios [2 ,3 ]
Vasile, Cornelia [1 ]
机构：
[1] Romanian Acad, Petru Poni Inst Macromol Chem, Phys Chem Polymers Lab, Iasi 700487, Romania
[2] Univ Patras, Dept Chem Engn, GR-26500 Patras, Greece
[3] ICE HT FORTH, Inst Chem Engn & High Temp Proc, GR-26500 Patras, Greece
来源：
JOURNAL OF APPLIED POLYMER SCIENCE | 2013年 / 127卷 / 05期
关键词：
thermothickening; sodium alginate; poly(N-isopropylacrylamide); graft copolymers; THERMOSENSITIVE GRAFT COPOLYMER; N-ISOPROPYLACRYLAMIDE; AQUEOUS-SOLUTION; THERMOASSOCIATIVE COPOLYMERS; SOLUTION BEHAVIOR; POLY(N-ISOPROPYLACRYLAMIDE); TEMPERATURE; ALGINATE; HYDROGELS; BACKBONE;
D O I：
10.1002/app.37789
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Stimuli-responsive biocompatible and biodegradable materials can be obtained by combining polysaccharides with polymers exhibiting lower critical solution temperature (LCST) phase behavior, such as poly(N-isopropylacrylamide) (PNIPAAm). The behavior of aqueous solutions of sodium alginate (NaAl) grafted with PNIPAAm (NaAl-g-PNIPAAm) copolymers as a function of composition and temperature is presented. The products obtained exhibit a remarkable thermothickening behavior in aqueous solutions if the degree of grafting, the concentration, and the temperature are higher than some critical values. The solgel-phase transition temperatures have been determined. It was found that at temperatures below LCST the systems behave like a solution, whereas at temperatures above LCST, the solutions behave like a stiff gel, because of PNIPAAm segregation. This behavior is reversible and could find applications in tissue engineering and drug delivery systems. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
引用
收藏
页码：3340 / 3348
页数：9
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