Behavioral and electrophysiological indices of temporal processing dysfunction in schizophrenia

被引:38
作者
Davalos, DB
Kisley, MA
Freedman, R
机构
[1] Denver VA Med Ctr, Denver, CO USA
[2] Univ Colorado, Hlth Sci Ctr, Colorado Springs, CO 80907 USA
关键词
D O I
10.1176/appi.neuropsych.17.4.517
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Timing deficits in schizophrenia have been noted in several behavioral studies. However, the involvement of mediating factors, such as inattention, has not been ruled out as contributing to these effects. Mismatch negativity (MMN), an electrophysiological measure, may provide a more direct index of stimulus processing ability in individuals with schizophrenia. The current study explored the relationship between behavioral time judgments and a time-based MMN paradigm. Participants were administered two MMN paradigms consisting of an "easy" or "difficult" deviant and an analogous behavioral measure of time processing. Matched against a healthy comparison group, patients exhibited decreased MMN amplitude on the "difficult" deviant interval only. However, on the behavioral paradigm, the patients made significantly more errors across all conditions. These results suggest that behavioral measures: of time processing may reflect different processes than those captured by preattentive physiological measures in this population.
引用
收藏
页码:517 / 525
页数:9
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