Exhaled Nitric Oxide

被引：25

作者：

Stewart, Lora ^{[2
]}

Katial, Rohit K. ^{[1
]}

机构：

[1] Natl Jewish Hlth, Div Allergy & Immunol, Denver, CO 80206 USA

[2] Allergy & Asthma Care & Prevent Ctr, Lone Tree, CO 80204 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2012年 / 32卷 / 03期

关键词：

Nitric oxide; Fractional concentration of exhaled NO; Asthma; Glucocorticoids; BRONCHIOLITIS OBLITERANS SYNDROME; OBSTRUCTIVE PULMONARY-DISEASE; CILIARY BEAT FREQUENCY; AIRWAY INFLAMMATION; CYSTIC-FIBROSIS; GLUCOCORTICOIDS INHIBIT; SPUTUM EOSINOPHILS; LUNG-FUNCTION; ASTHMA; CHILDREN;

D O I：

10.1016/j.iac.2012.06.005

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Nitric oxide (NO) is now considered an important biomarker for respiratory disease. Studies have confirmed that the fractional concentration of exhaled nitric oxide (FENO) is elevated in the airways of patients who have asthma in comparison with controls. The level of FENO correlates well with the presence and level of inflammation, and decreases with glucocorticoid treatment. NO has potential to be used not only as a diagnostic aid but also as a management tool for assessing severity, monitoring response to therapy, and gaining control of asthma symptoms. This article reviews the biology of NO and its role in respiratory disease.

引用

页码：347 / +

页数：17

共 106 条

[1]

Alving K, 2010, EUR RESPIR MONOGR, P1, DOI 10.1183/1025448x.00028509

[2]

ALVING K, 1993, EUR RESPIR J, V6, P1368

[3] ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 [J].

American Thoracic Society ;

European Respiratory Society .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (08) :912-930

[4] Exhaled nitric oxide in chronic obstructive pulmonary disease: relationship to pulmonary function [J].

Ansarin, K ;

Chatkin, JM ;

Ferreira, IM ;

Gutierrez, CA ;

Zamel, N ;

Chapman, KR .

EUROPEAN RESPIRATORY JOURNAL, 2001, 17 (05) :934-938

[5] Lower airway inflammation in infants and young children with cystic fibrosis [J].

Armstrong, DS ;

Grimwood, K ;

Carlin, JB ;

Carzino, R ;

Gutierrez, JP ;

Hull, J ;

Olinsky, A ;

Phelan, EM ;

Robertson, CF ;

Phelan, PD .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 156 (04) :1197-1204

[6] NITRIC-OXIDE IS THE ENDOGENOUS NEUROTRANSMITTER OF BRONCHODILATOR NERVES IN HUMANS [J].

BELVISI, MG ;

STRETTON, CD ;

YACOUB, M ;

BARNES, PJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 210 (02) :221-222

[7] A comparison of exhaled nitric oxide and induced sputum as markers of airway inflammation [J].

Berlyne, GS ;

Parameswaran, K ;

Kamada, D ;

Efthimiadis, A ;

Hargreave, FE .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 106 (04) :638-644

[8] Effects of exacerbations and seasonality on exhaled nitric oxide in COPD [J].

Bhowmik, A ;

Seemungal, TAR ;

Donaldson, GC ;

Wedzicha, JA .

EUROPEAN RESPIRATORY JOURNAL, 2005, 26 (06) :1009-1015

[9] Nitric oxide and reactive nitrogen species in airway epithelial signaling and inflammation [J].

Bove, Peter F. ;

van der Vliet, Albert .

FREE RADICAL BIOLOGY AND MEDICINE, 2006, 41 (04) :515-527

[10] Comparison of airway immunopathology of eosinophilic bronchitis and asthma [J].

Brightling, CE ;

Symon, FA ;

Birring, SS ;

Bradding, P ;

Wardlaw, AJ ;

Pavord, ID .

THORAX, 2003, 58 (06) :528-532

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