Complete remission after neoadjuvant chemotherapy of an advanced vulvar cancer patient: A case report

被引：6

作者：

Achilli, Chiara ^{[1
]}

Palaia, Innocenza ^{[1
]}

Perniola, Giorgia ^{[1
]}

Di Donato, Violante ^{[1
]}

Marchetti, Claudia ^{[1
]}

Panici, Pierluigi Benedetti ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Ginecol & Ostetricia, I-00161 Rome, Italy

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | 2012年 / 38卷 / 07期

关键词：

advanced vulvar cancer; neoadjuvant chemotherapy; vulvectomy; SQUAMOUS-CELL CARCINOMA; PREOPERATIVE CHEMORADIATION; BLEOMYCIN; METHOTREXATE; RECURRENT; EXENTERATION; SURVIVAL; SURGERY; CCNU;

D O I：

10.1111/j.1447-0756.2011.01821.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Invasive vulvar cancer has an incidence of 12/100 000 women per year and squamous cell carcinoma accounts for approximately 8590% of all vulvar cancers. Surgery has long been considered as the standard treatment, followed by chemotherapy in case of lymph node involvement. This approach is not only disfiguring, but also carries with it an operative mortality of up to 10%. Several studies have assessed the feasibility of radio-chemotherapy as definitive therapy and/or a neoadjuvant procedure. Nonetheless, combined radio-chemotherapy is associated with considerable toxicity. This study reports our experience with an unconventional schedule of neoadjuvant chemotherapy (topotecan and cisplatin) without radiotherapy in a patient with locally advanced vulvar cancer (International Federation of Gynecology and Obstetrics stage IIIA) who experienced complete clinical remission, followed by minimal surgical treatment.

引用

页码：1036 / 1039

页数：4

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