New and improved proteomics technologies for understanding complex biological systems: Addressing a grand challenge in the life sciences

被引：48

作者：

Hood, Leroy E. ^{[2
]}

Omenn, Gilbert S. ^{[1
,2
]}

Moritz, Robert L. ^{[2
]}

Aebersold, Ruedi ^{[3
]}

Yamamoto, Keith R. ^{[4
]}

Amos, Michael ^{[5
]}

Hunter-Cevera, Jennie ^{[6
]}

Locascio, Laurie ^{[5
]}

机构：

[1] Univ Michigan, Ctr Computat Med & Bioinformat, 2065 Palmer Commons, Ann Arbor, MI 48109 USA

[2] Inst Syst Biol, Seattle, WA USA

[3] Swiss Fed Inst Technol, Inst Mol Syst Biol, Zurich, Switzerland

[4] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

[5] NIST, Dept Commerce, Gaithersburg, MD 20899 USA

[6] RTI, Res Triangle Pk, NC USA

来源：

PROTEOMICS | 2012年 / 12卷 / 18期

关键词：

Complex systems; Democratization of proteomics; Economic growth; Grand challenges; Integration; Systems biology; PROTEINS; CAPTURE;

D O I：

10.1002/pmic.201270086

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This White Paper sets out a Life Sciences Grand Challenge for Proteomics Technologies to enhance our understanding of complex biological systems, link genomes with phenotypes, and bring broad benefits to the biosciences and the US economy. The paper is based on a workshop hosted by the National Institute of Standards and Technology (NIST) in Gaithersburg, MD, 1415 February 2011, with participants from many federal R&D agencies and research communities, under the aegis of the US National Science and Technology Council (NSTC). Opportunities are identified for a coordinated R&D effort to achieve major technology-based goals and address societal challenges in health, agriculture, nutrition, energy, environment, national security, and economic development.

引用

页码：2773 / 2783

页数：11