Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays

被引：230

作者：

Hovestadt, Volker ^{[1
]}

Remke, Marc ^{[2
,3
,4
,5
]}

Kool, Marcel ^{[6
]}

Pietsch, Torsten ^{[7
]}

Northcott, Paul A. ^{[6
]}

Fischer, Roger ^{[8
]}

Cavalli, Florence M. G. ^{[2
,3
]}

Ramaswamy, Vijay ^{[2
,3
,4
,5
]}

Zapatka, Marc ^{[1
]}

Reifenberger, Guido ^{[9
]}

Rutkowski, Stefan ^{[10
]}

Schick, Matthias ^{[8
]}

Bewerunge-Hudler, Melanie ^{[8
]}

Korshunov, Andrey ^{[11
,12
]}

Lichter, Peter ^{[1
]}

Taylor, Michael D. ^{[2
,3
,4
,5
]}

Pfister, Stefan M. ^{[6
,13
]}

Jones, David T. W. ^{[6
]}

机构：

[1] German Canc Res Ctr, Div Mol Genet, D-69120 Heidelberg, Germany

[2] Hosp Sick Children, Program Dev & Stem Cell Biol, Toronto, ON M5G 1X8, Canada

[3] Hosp Sick Children, Arthur & Sonja Labatt Brain Tumour Res Ctr, Toronto, ON M5G 1X8, Canada

[4] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[5] Hosp Sick Children, Div Neurosurg, Toronto, ON M5G 1X8, Canada

[6] German Canc Res Ctr, Div Pediat Neurooncol, D-69120 Heidelberg, Germany

[7] Univ Bonn, Med Ctr, Dept Neuropathol, D-53105 Bonn, Germany

[8] German Canc Res Ctr, Genom & Prote Core Facil, D-69120 Heidelberg, Germany

[9] Univ Dusseldorf, Dept Neuropathol, D-40225 Dusseldorf, Germany

[10] Univ Med Ctr Hamburg Eppendorf, Dept Pediat Hematol & Oncol, D-20246 Hamburg, Germany

[11] Heidelberg Univ, Dept Neuropathol, D-69120 Heidelberg, Germany

[12] German Canc Res Ctr, Clin Cooperat Unit Neuropathol, D-69120 Heidelberg, Germany

[13] Univ Heidelberg Hosp, Dept Pediat Oncol Hematol & Immunol, D-69120 Heidelberg, Germany

来源：

ACTA NEUROPATHOLOGICA | 2013年 / 125卷 / 06期

关键词：

Medulloblastoma; Rand Index; Consensus Cluster; 450k Array; FFPE Material;

D O I：

10.1007/s00401-013-1126-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

引用

页码：913 / 916

页数：4

共 15 条

[1] A phase I pharmacokinetic trial of sonic hedgehog (SHH) antagonist GDC-0449 in pediatric patients with recurrent or refractory medulloblastoma: A Pediatric Brain Tumor Consortium study (PBTC 25) [J].

Gajjar, A. J. ;

Stewart, C. F. ;

Ellison, D. W. ;

Curran, T. ;

Phillips, P. ;

Goldman, S. ;

Packer, R. ;

Kun, L. E. ;

Boyett, J. M. ;

Gilbertson, R. J. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (18)

[2]

Geoerger B., 2012, J CLIN ONCOL S, V30

[3] Dissecting the genomic complexity underlying medulloblastoma [J].

Jones, David T. W. ;

Jaeger, Natalie ;

Kool, Marcel ;

Zichner, Thomas ;

Hutter, Barbara ;

Sultan, Marc ;

Cho, Yoon-Jae ;

Pugh, Trevor J. ;

Hovestadt, Volker ;

Stuetz, Adrian M. ;

Rausch, Tobias ;

Warnatz, Hans-Joerg ;

Ryzhova, Marina ;

Bender, Sebastian ;

Sturm, Dominik ;

Pleier, Sabrina ;

Cin, Huriye ;

Pfaff, Elke ;

Sieber, Laura ;

Wittmann, Andrea ;

Remke, Marc ;

Witt, Hendrik ;

Hutter, Sonja ;

Tzaridis, Theophilos ;

Weischenfeldt, Joachim ;

Raeder, Benjamin ;

Avci, Meryem ;

Amstislavskiy, Vyacheslav ;

Zapatka, Marc ;

Weber, Ursula D. ;

Wang, Qi ;

Lasitschka, Baerbel ;

Bartholomae, Cynthia C. ;

Schmidt, Manfred ;

von Kalle, Christof ;

Ast, Volker ;

Lawerenz, Chris ;

Eils, Juergen ;

Kabbe, Rolf ;

Benes, Vladimir ;

van Sluis, Peter ;

Koster, Jan ;

Volckmann, Richard ;

Shih, David ;

Betts, Matthew J. ;

Russell, Robert B. ;

Coco, Simona ;

Tonini, Gian Paolo ;

Schueller, Ulrich ;

Hans, Volkmar .

NATURE, 2012, 488 (7409) :100-105

[4] Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas [J].

Kool, Marcel ;

Korshunov, Andrey ;

Remke, Marc ;

Jones, David T. W. ;

Schlanstein, Maria ;

Northcott, Paul A. ;

Cho, Yoon-Jae ;

Koster, Jan ;

Schouten-van Meeteren, Antoinette ;

van Vuurden, Dannis ;

Clifford, Steven C. ;

Pietsch, Torsten ;

von Bueren, Andre O. ;

Rutkowski, Stefan ;

McCabe, Martin ;

Collins, V. Peter ;

Backlund, Magnus L. ;

Haberler, Christine ;

Bourdeaut, Franck ;

Delattre, Olivier ;

Doz, Francois ;

Ellison, David W. ;

Gilbertson, Richard J. ;

Pomeroy, Scott L. ;

Taylor, Michael D. ;

Lichter, Peter ;

Pfister, Stefan M. .

ACTA NEUROPATHOLOGICA, 2012, 123 (04) :473-484

[5] Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia [J].

Kulis, Marta ;

Heath, Simon ;

Bibikova, Marina ;

Queiros, Ana C. ;

Navarro, Alba ;

Clot, Guillem ;

Martinez-Trillos, Alejandra ;

Castellano, Giancarlo ;

Brun-Heath, Isabelle ;

Pinyol, Magda ;

Barberan-Soler, Sergio ;

Papasaikas, Panagiotis ;

Jares, Pedro ;

Bea, Silvia ;

Rico, Daniel ;

Ecker, Simone ;

Rubio, Miriam ;

Royo, Romina ;

Ho, Vincent ;

Klotzle, Brandy ;

Hernandez, Lluis ;

Conde, Laura ;

Lopez-Guerra, Monica ;

Colomer, Dolors ;

Villamor, Neus ;

Aymerich, Marta ;

Rozman, Maria ;

Bayes, Monica ;

Gut, Marta ;

Gelpi, Josep L. ;

Orozco, Modesto ;

Fan, Jian-Bing ;

Quesada, Victor ;

Puente, Xose S. ;

Pisano, David G. ;

Valencia, Alfonso ;

Lopez-Guillermo, Armando ;

Gut, Ivo ;

Lopez-Otin, Carlos ;

Campo, Elias ;

Martin-Subero, Jose I. .

NATURE GENETICS, 2012, 44 (11) :1236-1242

[6] Medulloblastomics: the end of the beginning [J].

Northcott, Paul A. ;

Jones, David T. W. ;

Kool, Marcel ;

Robinson, Giles W. ;

Gilbertson, Richard J. ;

Cho, Yoon-Jae ;

Pomeroy, Scott L. ;

Korshunov, Andrey ;

Lichter, Peter ;

Taylor, Michael D. ;

Pfister, Stefan M. .

NATURE REVIEWS CANCER, 2012, 12 (12) :818-834

[7] Subgroup-specific structural variation across 1,000 medulloblastoma genomes [J].

Northcott, Paul A. ;

Shih, David J. H. ;

Peacock, John ;

Garzia, Livia ;

Morrissy, A. Sorana ;

Zichner, Thomas ;

Stuetz, Adrian M. ;

Korshunov, Andrey ;

Reimand, Jueri ;

Schumacher, Steven E. ;

Beroukhim, Rameen ;

Ellison, David W. ;

Marshall, Christian R. ;

Lionel, Anath C. ;

Mack, Stephen ;

Dubuc, Adrian ;

Yao, Yuan ;

Ramaswamy, Vijay ;

Luu, Betty ;

Rolider, Adi ;

Cavalli, Florence M. G. ;

Wang, Xin ;

Remke, Marc ;

Wu, Xiaochong ;

Chiu, Readman Y. B. ;

Chu, Andy ;

Chuah, Eric ;

Corbett, Richard D. ;

Hoad, Gemma R. ;

Jackman, Shaun D. ;

Li, Yisu ;

Lo, Allan ;

Mungall, Karen L. ;

Nip, Ka Ming ;

Qian, Jenny Q. ;

Raymond, Anthony G. J. ;

Thiessen, Nina ;

Varhol, Richard J. ;

Birol, Inanc ;

Moore, Richard A. ;

Mungall, Andrew J. ;

Holt, Robert ;

Kawauchi, Daisuke ;

Roussel, Martine F. ;

Kool, Marcel ;

Jones, David T. W. ;

Witt, Hendrick ;

Fernandez-L, Africa ;

Kenney, Anna M. ;

Wechsler-Reya, Robert J. .

NATURE, 2012, 488 (7409) :49-56

[8] Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples [J].

Northcott, Paul A. ;

Shih, David J. H. ;

Remke, Marc ;

Cho, Yoon-Jae ;

Kool, Marcel ;

Hawkins, Cynthia ;

Eberhart, Charles G. ;

Dubuc, Adrian ;

Guettouche, Toumy ;

Cardentey, Yoslayma ;

Bouffet, Eric ;

Pomeroy, Scott L. ;

Marra, Marco ;

Malkin, David ;

Rutka, James T. ;

Korshunov, Andrey ;

Pfister, Stefan ;

Taylor, Michael D. .

ACTA NEUROPATHOLOGICA, 2012, 123 (04) :615-626

[9] Medulloblastoma Comprises Four Distinct Molecular Variants [J].

Northcott, Paul A. ;

Korshunov, Andrey ;

Witt, Hendrik ;

Hielscher, Thomas ;

Eberhart, Charles G. ;

Mack, Stephen ;

Bouffet, Eric ;

Clifford, Steven C. ;

Hawkins, Cynthia E. ;

French, Pim ;

Rutka, James T. ;

Pfister, Stefan ;

Taylor, Michael D. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (11) :1408-1414

[10] Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma [J].

Noushmehr, Houtan ;

Weisenberger, Daniel J. ;

Diefes, Kristin ;

Phillips, Heidi S. ;

Pujara, Kanan ;

Berman, Benjamin P. ;

Pan, Fei ;

Pelloski, Christopher E. ;

Sulman, Erik P. ;

Bhat, Krishna P. ;

Verhaak, Roel G. W. ;

Hoadley, Katherine A. ;

Hayes, D. Neil ;

Perou, Charles M. ;

Schmidt, Heather K. ;

Ding, Li ;

Wilson, Richard K. ;

Van Den Berg, David ;

Shen, Hui ;

Bengtsson, Henrik ;

Neuvial, Pierre ;

Cope, Leslie M. ;

Buckley, Jonathan ;

Herman, James G. ;

Baylin, Stephen B. ;

Laird, Peter W. ;

Aldape, Kenneth .

CANCER CELL, 2010, 17 (05) :510-522

← 1 2 →