Artemether treatment of recrudescent Plasmodium falciparum malaria in children

被引：4

作者：

Sowunmi, A

Odulola, AMJ

机构：

[1] UNIV IBADAN,DEPT THERAPEUT & PHARMACOL,IBADAN,NIGERIA

[2] UNIV IBADAN,POSTGRAD INST MED RES & TRAINING,IBADAN,NIGERIA

来源：

TROPICAL MEDICINE & INTERNATIONAL HEALTH | 1997年 / 2卷 / 07期

关键词：

recrudescence; severe falciparum malaria; artemether;

D O I：

10.1046/j.1365-3156.1997.d01-347.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Intramuscular artemether given for five days was evaluated prospectively in 32 patients with acute recrudescent Plasmodium falciparum malaria. All patients had experienced one or more treatment failures with one or more courses of the following drugs: chloroquine, amodiaquine, sulphadoxine-pyrimethamine and erythromycin given alone or in combination. There was a prompt response to treatment with fever and parasite clearance times of 10.7 (3.6) h (range 6-24) and 32.3 (8.3) h (range 24-48) respectively. Parasite reduction at 24 h was 91.2 (7.8)% (range 75-100), The cure rate on day 14 was 100%. The drug was well tolerated. These results suggest that artemether is rapidly effective in acute recrudescent Plasmodium falciparum malaria and is without deleterious side effects.

引用

页码：631 / 634

页数：4

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