Rhodium(III)-catalyzed C-H amination of 2-arylquinazolin-4(3H)-one with N-alkyl-O-benzoyl-hydroxylamines

被引：18
|
作者：
Zhang, Yuanguang [1 ]
Huang, Jiang [1 ]
Deng, Zhihong [1 ]
Mao, Xunchun [1 ]
Peng, Yiyuan [1 ]
机构：
[1] Jiangxi Normal Univ, Jiangxi Prov Key Lab Green Chem, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China
来源：
TETRAHEDRON | 2018年 / 74卷 / 19期
基金：
中国国家自然科学基金;
关键词：
C-H activation; Amination; Rh-catalyzed; 2-arylquinazolin-4(3H)-one; CATALYZED ELECTROPHILIC AMINATION; DIRECTING-GROUP; BOND ACTIVATION; AMIDATION; ARENES; DERIVATIVES; QUINAZOLINONE; AZIDES; ROUTE; SITE;
D O I：
10.1016/j.tet.2018.03.051
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-benzoate alkylamines were used as the aminating agents, a efficient Rh-catalyzed ortho C-H amination of 2-arylquinazolin-4(3H)-one has been reported. The reactions exhibit high efficient and good functional group tolerance. Exclusive 2,6-bis-aminated product and good to excellent yields were obtained under mild reaction conditions. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2330 / 2337
页数：8
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