The Role of Ghrelin in Anorexia-Cachexia Syndromes

被引:27
作者
Guillory, Bobby [1 ]
Splenser, Andres [1 ]
Garcia, Jose [1 ,2 ]
机构
[1] Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Div Diabet Endocrinol & Metab, Houston, TX 77030 USA
[2] Baylor Coll Med, Huffington Ctr Aging, Dept Mol & Cell Biol, Houston, TX 77030 USA
来源
ANOREXIA | 2013年 / 92卷
关键词
GROWTH-HORMONE SECRETAGOGUE; DES-ACYL GHRELIN; LEAN BODY-MASS; MUSCLE PROTEIN BREAKDOWN; O-ACYLTRANSFERASE GOAT; CHRONIC-RENAL-FAILURE; FACTOR-KAPPA-B; SKELETAL-MUSCLE; MESSENGER-RNA; FOOD-INTAKE;
D O I
10.1016/B978-0-12-410473-0.00003-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Anorexia, sarcopenia, and cachexia are common complications of many chronic conditions including cancer, rheumatoid arthritis, HIV infection, aging, and chronic lung, heart, or kidney disease. Currently, there is no effective treatment for muscle atrophy or wasting conditions although they typically take a significant toll on the quality of life of patients and are associated with poor prognosis and decreased survival. Ghrelin affects multiple key pathways in the regulation of body weight, body composition, and appetite in the setting of cachexia that may lead to an increase in appetite and growth hormone secretion and a reduction in energy expenditure and inflammation. The net effect is increased lean body mass and fat mass preservation. In this chapter, we review the mechanisms of action of ghrelin and present the available data in animal models and human trials using ghrelin or ghrelin mimetics in different settings of cachexia.
引用
收藏
页码:61 / +
页数:16
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