Antiretroviral Regimens Containing a Single Protease Inhibitor Increase Risk of Virologic Failure in Young HIV-infected Children

被引：4

作者：

Walters, Elisabetta ^{[1
]}

Reichmuth, Kirsten ^{[2
]}

Dramowski, Angela ^{[3
]}

Marais, Ben J. ^{[4
]}

Cotton, Mark F. ^{[3
]}

Rabie, Helena ^{[3
]}

机构：

[1] Univ Stellenbosch, Desmond Tutu TB Ctr, Dept Paediat & Child Hlth, Cape Town, South Africa

[2] Univ Cape Town, Dept Paediat, ZA-7925 Cape Town, South Africa

[3] Univ Stellenbosch, Tygerberg Childrens Hosp, Dept Paediat & Child Hlth, Cape Town, South Africa

[4] Univ Sydney, Childrens Hosp Westmead, Sydney Inst Emerging Infect & Biosecur, Dept Paediat & Child Hlth, Sydney, NSW 2006, Australia

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2013年 / 32卷 / 04期

关键词：

antiretroviral therapy; tuberculosis; virologic failure; TUBERCULOSIS; RIFAMPICIN;

D O I：

10.1097/INF.0b013e318279c800

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rifampin-based tuberculosis treatment can cause subtherapeutic concentrations of protease inhibitors and virologic failure in children receiving antiretroviral therapy. Among 217 children on antiretroviral therapy, tuberculosis cotreatment (in 78) was associated with virologic failure. Ritonavir-based single protease inhibitor antiretroviral therapy regimen predicted virologic failure (adjusted odds ratio 3.7, 95% confidence interval 1.5-8.9, P = 0.004) on multivariate analysis.

引用

页码：361 / 363

页数：3

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