Rutin and curcumin reduce inflammation, triglyceride levels and ADA activity in serum and immune cells in a model of hyperlipidemia

被引：46

作者：

Manzoni, Alessandra G. ^{[1
,2
]}

Passos, Daniela F. ^{[1
,2
]}

da Silva, Jean L. G. ^{[1
,2
]}

Bernardes, Viviane M. ^{[1
,2
]}

Bremm, Joao M. ^{[1
]}

Jantsch, Matheus H. ^{[1
]}

de Oliveira, Juliana S. ^{[2
,3
]}

Mann, Thais R. ^{[3
]}

de Andrade, Cinthia M. ^{[2
,3
]}

Leal, Daniela B. R. ^{[1
,2
]}

机构：

[1] Univ Fed Santa Maria, Lab Imunobiol Expt & Aplicada LABIBIO, Dept Microbiol & Parasitol, Ctr Ciencias Saude, Santa Maria, RS, Brazil

[2] Univ Fed Santa Maria, Programa Posgrad Bioquim Toxicol, Ctr Ciencias Nat & Exatas, Santa Maria, RS, Brazil

[3] Univ Fed Santa Maria, Lab Patol Clin Vet, Dept Clin Pequenos Anim, Ctr Ciencias Rurais, Santa Maria, RS, Brazil

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2019年 / 76卷

关键词：

Hyperlipidemia; Rutin; Curcumin; Adenosine deaminase; Oxidative stress; HYDROLYZE ADENINE-NUCLEOTIDES; ADENOSINE-DEAMINASE ACTIVITY; TO-LYMPHOCYTE RATIO; LIPID-PEROXIDATION; PROGNOSTIC MARKER; ATHEROSCLEROSIS; PLATELET; HYPERCHOLESTEROLEMIA; NEUTROPHIL; ENZYMES;

D O I：

10.1016/j.bcmd.2018.12.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hyperlipidemia is associated with endothelial dysfunction and inflammatory disorders. Adenosine and adenosine deaminase (ADA) modulate immune responses and lipid metabolism. Curcumin and rutin are polyphenols with antioxidant, anti-inflammatory, and hypolipidemic effects. We evaluated the action of rutin and curcumin in the lipid levels and inflammation, as well as their effect on ADA activity in serum, lymphocytes, platelets, and neutrophils of hyperlipidemic rats. Adult male Wistar rats pretreated with curcumin and/or rutin for 30 days were submitted to Poloxamer-407- induced hyperlipidemia. Biochemical, hematological, and oxidative stress parameters, as well as serum and extracellular ADA activity, were performed 36h post-induction. Hyperlipidemia was confirmed by the increase in total cholesterol (TC) and triglycerides (TG). Hematological alterations, elevated reactive oxygen species (ROS) levels, and increased myeloperoxidase (MPO) and ADA activities were observed in hyperlipidemic rats. Curcumin and the curcumin/rutin association decreased TG and increased high-density lipids (HDL) levels. The pretreatments prevented changes in the hematological parameters, decreased the activities of MPO in plasma and ADA in serum and cells. Cholesterol and ROS levels were not altered by the pretreatments. Our results show that pretreatments with rutin and/or curcumin prevent the hyperlipidemia-induced inflammation. Pretreatments with curcumin and/or rutin are potential complementary therapies in the prevention of hypertriglyceridemia and inflammation.

引用

页码：13 / 21

页数：9