Resuscitation with polymerized human placenta hemoglobin attenuated hemorrhagic shock-induced lung injury

被引：6
作者：
Li, Tao [1 ,2 ]
Zhang, Zhenyu [3 ]
Wu, Wei [4 ]
Liao, Daqin [1 ,2 ]
Chen, Yanfang [1 ,2 ]
Li, Shen [5 ]
Yang, Chengmin [5 ]
Xu, Xuewen [3 ]
Liu, Jin [1 ,2 ]
机构：
[1] Sichuan Univ, Lab Anesthesiol, West China Hosp, Chengdu 610041, Peoples R China
[2] Sichuan Univ, Translat Neurosci Ctr, West China Hosp, Chengdu 610041, Peoples R China
[3] Sichuan Univ, Dept Burn & Plast Surg, West China Hosp, Chengdu 610041, Peoples R China
[4] Chengdu Army Gen Hosp, Dept Anesthesiol, Chengdu, Peoples R China
[5] Chinese Acad Med Sci, Inst Blood Transfus, Chengdu, Peoples R China
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2013年 / 41卷 / 01期
关键词：
Hemoglobin-based oxygen carrier; hemorrhagic shock; pulmonary function; inflammation; ISCHEMIA-REPERFUSION INJURY; ORGAN DYSFUNCTION; OXYGEN CARRIER; HEART; NEUTROPHILS; RATS;
D O I：
10.3109/10731199.2012.696061
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This study was designed to investigate whether polymerized human placenta hemoglobin (PolyPHb) attenuated hemorrhagic shock-induced lung injury. A mean arterial pressure (MAP) of 30mmHg was maintained for 60 min. Then, all the rats were randomly resuscitated with hetastarch, whole blood, or PolyPHb. The result indicated that PolyPHb greatly improved the MAP and pulmonary function, and significantly reduced the release of inflammatory cytokines, histopathological changes, and pulmonary edema. Therefore, our findings suggest that PolyPHb could reduce pulmonary injury after hemorrhagic shock, and this effect was probably associated with the depressed inflammatory response.
引用
收藏
页码：27 / 31
页数：5
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