Synthesis of novel polyesteramine dendrimers by divergent and convergent methods

Novel dendrimers having an adamantane structure as a core were synthesized such that even low generation dendrimers had a globular structure. Moreover we tried to give them biodegradable function by using ester bonds. Synthesis of the dendrimers, particularly at higher generations, proved difficult via a stepwise procedure, and thus a convergent route was used in which the adamantane core is coupled to the dendritic segments in the final step. We achieved the synthesis of two separate dendrimers with convergent methods till the third generations. The convergent dendrimers were synthesized in good yields compared with divergent one and both dendrimers were found to have narrow polydispersities by GPC analysis. (C) 2013 Elsevier Ltd. All rights reserved.