Sedation methods can determine performance of endoscopic submucosal dissection in patients with gastric neoplasia

被引:42
作者
Park, Chan Hyuk [1 ]
Min, Jae Hoon [1 ]
Yoo, Young-Chul [2 ]
Kim, Hyunzu [2 ]
Joh, Dong Hoo [1 ]
Jo, Jung Hyun [1 ]
Shin, Suji [1 ]
Lee, Hyuk [1 ]
Park, Jun Chul [1 ]
Shin, Sung Kwan [1 ]
Lee, Yong Chan [1 ]
Lee, Sang Kil [1 ]
机构
[1] Yonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol,Yonsei Inst Gastroenterol, Seoul, South Korea
[2] Yonsei Univ, Coll Med, Dept Anesthesiol, Seoul, South Korea
来源
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | 2013年 / 27卷 / 08期
关键词
Endoscopic submucosal dissection; Midazolam; Propofol; Sedation; PROPOFOL SEDATION; GASTROINTESTINAL ENDOSCOPY; ADMINISTERED PROPOFOL; MUCOSAL RESECTION; GAG REFLEX; OUTCOMES; GASTROENTEROLOGIST; FENTANYL; CANCER; ESD;
D O I
10.1007/s00464-013-2804-z
中图分类号
R61 [外科手术学];
学科分类号
摘要
Although proper sedation is mandatory for endoscopic procedures such as endoscopic submucosal dissection (ESD), there is no research investigating the effects of sedation on ESD performance and complications. We aimed to evaluate the relationship among sedation methods, clinical outcomes, and complications after ESD for gastric neoplasia. We retrospectively reviewed clinical data of 1,367 patients with 1,485 lesions who had undergone ESD for gastric adenoma or early gastric cancer at our tertiary teaching hospital in Seoul, Korea, between January 2008 and May 2011. Of these, 1,035 lesions in 958 patients were included in the intermittent midazolam/propofol injection by endoscopists (IMIE) group, and 450 lesions in 409 patients were included in the continuous propofol infusion with opioid administration by anesthesiologists (CPIA) group. En bloc resection and complete resection rates were higher in the CPIA group than in the IMIE group (CPIA vs. IMIE; en bloc resection, 99.8 and 95.0 %, P < 0.001; complete resection, 94.2 and 88.3 %, P < 0.001). Duration of procedure was shorter in the CPIA group than in the IMIE group (CPIA vs. IMIE; 48.2 +/- A 32.5 and 57.6 +/- A 41.3 min, P < 0.001). In multivariate analysis, sedation method was an independent factor associated with en bloc resection and complete resection. Additionally, sedation with CPIA was not a risk factor for bleeding (P = 0.403) or perforation (P = 0.474); however, aspiration pneumonia developed more frequently in patients sedated with CPIA (CPIA vs. IMIE, 4.4 and 1.5 %, P = 0.002). Sedation with CPIA can improve ESD performance.
引用
收藏
页码:2760 / 2767
页数:8
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