Single wall carbon nanohorn as a drug carrier for controlled release

被引：66

作者：

Xu, Jianxun ^{[1
,2
]}

Yudasaka, Masako ^{[1
,3
]}

Kouraba, Sachio ^{[4
]}

Sekido, Mitsuru ^{[4
]}

Yamamoto, Yuhei ^{[4
]}

Iijima, Sumio ^{[1
,2
,3
]}

机构：

[1] JST, SORST, NEC, Tsukuba, Ibaraki 3058501, Japan

[2] Meijo Univ, Dept Mat, Tenpaku Ku, Nagoya, Aichi 4688502, Japan

[3] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058565, Japan

[4] Hokkaido Univ, Grad Sch Med, Dept Plast & Reconstruct Surg, Kita Ku, Sapporo, Hokkaido 0608637, Japan

来源：

CHEMICAL PHYSICS LETTERS | 2008年 / 461卷 / 4-6期

关键词：

D O I：

10.1016/j.cplett.2008.06.077

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A single wall carbon nanohorn (SWNH) is a new kind of single-graphene tubules with a diameter of 2-5 nm and a length 40-50 nm. In this work, we used oxidized SWNH (SWNHox) to incorporate vancomycin hydrochloride (VCM) for its controlled release by taking advantage of the interactions between VCM and SWNHox. Phospholipid-poly(ethylene glycol) was used to modify the hydrophobic surface of SWNHox to improve its dispersion in aqueous systems. In the release study using this complex, a stable release of VCM was achieved for an extended period. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：189 / 192

页数：4

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