Role of Intestinal Microbiome in Lipid and Glucose Metabolism in Diabetes Mellitus

被引:52
作者
van Olden, Casper [1 ]
Groen, Albert K. [1 ,2 ]
Nieuwdorp, Max [1 ,3 ,4 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, Lab Metab Dis, NL-9700 AB Groningen, Netherlands
[3] Free Univ Amsterdam, Med Ctr, Dept Internal Med, VUmc Diabet Ctr, Amsterdam, Netherlands
[4] Univ Gothenberg, Wallenberg Lab, Gothenburg, Sweden
关键词
glucose; lipids; metabolism; microbiome; diabetes; PROTEIN-COUPLED RECEPTOR; CHAIN FATTY-ACIDS; GUT MICROBIOTA; PEPTIDE-1; SECRETION; ADIPOSE-TISSUE; T-CELLS; OBESITY; ENDOTOXEMIA; MODULATION; IMPACT;
D O I
10.1016/j.clinthera.2015.03.008
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Purpose: The contribution of intestinal bacterial strains (gut microbiota) in human metabolism and obesity is being increasingly recognized. The goal of this article was to provide a commentary on the clinical usefulness of these data. Methods: We performed a review of the currently available articles on PubMed. Findings: Because most of the data are based on germ-free animal research, translation to human disease may be difficult. However, changes in the intestinal bacterial composition and subsequent altered diversity have been associated with the presence of chronic low-grade inflammation, a known feature of insulin resistance and type 2 diabetes mellitus. Implications: It is still not proven whether intestinal bacteria play a causal role in glucose and lipid metabolism. Intervention studies including fecal transplantation and supplementation of single bacterial strains in humans might provide more insight. Moreover, prospective cohorts of healthy subjects using fecal samples collected at baseline can help to identify causally involved specific intestinal bacterial strains that drive aberrant human metabolism. Ultimately, it would be a great asset if potential diagnostic and therapeutic targets could be derived from this novel player in human cardiometabolism. (C) 2015 Elsevier HS Journals, Inc. All rights reserved.
引用
收藏
页码:1172 / 1177
页数:6
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