Oxygen Metabolism in Ischemic Stroke Using Magnetic Resonance Imaging
被引:18
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作者:
An, Hongyu
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机构:
Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
Univ N Carolina, Biomed Res Imaging Ctr, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
An, Hongyu
[1
,2
]
Liu, Qingwei
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机构:
Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
Univ N Carolina, Biomed Res Imaging Ctr, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
Liu, Qingwei
[1
,2
]
Chen, Yasheng
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机构:
Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
Univ N Carolina, Biomed Res Imaging Ctr, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
Chen, Yasheng
[1
,2
]
Vo, Katie D.
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机构:
Washington Univ, Dept Radiol, St Louis, MO USAUniv N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
Vo, Katie D.
[3
]
Ford, Andria L.
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机构:
Washington Univ, Dept Neurol, St Louis, MO USAUniv N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
Ford, Andria L.
[4
]
Lee, Jin-Moo
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机构:
Washington Univ, Dept Neurol, St Louis, MO USAUniv N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
Lee, Jin-Moo
[4
]
Lin, Weili
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机构:
Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
Univ N Carolina, Biomed Res Imaging Ctr, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
Lin, Weili
[1
,2
]
机构:
[1] Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Biomed Res Imaging Ctr, Chapel Hill, NC 27599 USA
[3] Washington Univ, Dept Radiol, St Louis, MO USA
[4] Washington Univ, Dept Neurol, St Louis, MO USA
Detecting "at-risk" but potentially salvageable brain tissue, known as the ischemic penumbra, is of importance for identifying patients who may benefit from thrombolytic or other treatments beyond the currently FDA-approved short therapeutic window for tissue plasminogen activator. Since the magnetic resonance blood oxygenation level-dependent (BOLD) contrast may provide information concerning tissue oxygen metabolism, its utilization in ischemic stroke has been explored. The focus of this review is to provide an introduction of several BOLD-based methods, including susceptibility-weighted imaging, R2 BOLD, R2*, R2', MR_OEF, and MR_OMI approaches to assess cerebral oxygenation changes induced by ischemia. Specifically, we will review the underlying pathophysiological basis of the imaging approaches, followed by a brief introduction of BOLD contrast, and finally the applications of BOLD approaches in ischemic stroke. The advantages and disadvantages of each method are addressed. In summary, the BOLD-based methods are promising for imaging oxygenation in ischemic tissue. Future steps would include technical refinement and vigorous validation against another independent method, such as positron emission tomography.
机构:
Department of Neurology - VBK 915, Massachusetts General Hospital, Boston, MA 02114-2622Department of Neurology - VBK 915, Massachusetts General Hospital, Boston, MA 02114-2622
Sitburana O.
Koroshetz W.J.
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机构:
Department of Neurology - VBK 915, Massachusetts General Hospital, Boston, MA 02114-2622Department of Neurology - VBK 915, Massachusetts General Hospital, Boston, MA 02114-2622
机构:
Fed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Moscow, Russia
Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Moscow, RussiaFed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Moscow, Russia
Namestnikova, D. D.
Cherkashova, E. A.
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机构:
Fed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Moscow, Russia
Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Moscow, RussiaFed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Moscow, Russia
Cherkashova, E. A.
Gumin, I. S.
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机构:
Fed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Moscow, RussiaFed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Moscow, Russia
Gumin, I. S.
Chekhonin, V. P.
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机构:
Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Moscow, Russia
Minist Hlth Russian Federat, VP Serbsky Natl Med Res Ctr Psychiat & Narcol, Moscow, RussiaFed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Moscow, Russia
Chekhonin, V. P.
Yarygin, K. N.
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机构:
VN Orekhovich Res Inst Biomed Chem, Moscow, Russia
Russian Med Acad Continuous Profess Educ, Minist Hlth Russian Federat, Moscow, RussiaFed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Moscow, Russia
Yarygin, K. N.
Gubskiy, I. L.
论文数: 0引用数: 0
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机构:
Fed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Moscow, Russia
Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Moscow, RussiaFed Med Biol Agcy Russia, Fed Ctr Brain Res & Neurotechnol, Moscow, Russia