Gold-Catalyzed Functionalization of Unactivated C(sp3)-H Bonds by Hydride Transfer Facilitated by Alkynylspirocyclopropanes

被引：49

作者：

Barluenga, Jose ^{[1
,2
]}

Sigueeiro, Rita ^{[1
,2
]}

Vicente, Ruben ^{[1
,2
]}

Ballesteros, Alfredo ^{[1
,2
]}

Tomas, Miguel ^{[1
,2
]}

Rodriguez, Miguel A. ^{[3
]}

机构：

[1] Univ Oviedo, Dept Quim Organ & Inorgan, E-33006 Oviedo, Spain

[2] Univ Oviedo, Inst Univ Quim Organomet Enrique Moles, E-33006 Oviedo, Spain

[3] Univ La Rioja, Dept Quim, Ctr Invest Sintesis Quim, Logrono 26006, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 41期

关键词：

C(sp3)?H bond cleavage; cyclization; gold; homogeneous catalysis; hydride transfer; C-H BOND; FISCHER CARBENE COMPLEXES; TERMINAL ALKYNES; RING EXPANSIONS; METAL; ACTIVATION; CYCLOISOMERIZATION; REARRANGEMENTS; ARYLATION; PLATINUM;

D O I：

10.1002/anie.201205051

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Golden Gate: Alkynylspirocyclopropanes served as a template for the development of gold-catalyzed hydride transfer from unactivated C(sp 3)-H bonds to electronically neutral alkynes. A variety of interesting carbocyclic structures can be accessed selectively with the appropriate choice of the reaction conditions. Mechanistic studies support a sequential gold-catalyzed cleavage of C-H and C-C bonds. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：10377 / 10381

页数：5

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