Synthesis and structure of new 1,3-disubstituted 5-oxopyrrolidine derivatives

被引：0

作者：

Intaite, Vida ^{[1
]}

Voskiene, Ausra ^{[1
]}

Vaickelioniene, Rita ^{[1
]}

Mikulskiene, Gema ^{[2
]}

Mickevicius, Vytautas ^{[1
]}

机构：

[1] Kaunas Univ Technol, Dept Organ Chem, LT-50254 Kaunas, Lithuania

[2] Vilnius Univ, Inst Biochem, Dept Biochem Xenobiot, LT-08662 Vilnius, Lithuania

来源：

CHEMIJA | 2012年 / 23卷 / 01期

关键词：

5-oxo-1-phenylpyrrolidine-3-carbohydrazides; cyclization; azoles; isomerism; NMR spectroscopy; BIOLOGICAL-ACTIVITY; NMR; 1,3,4-OXADIAZOLE; C-13; 1,3,4-THIADIAZOLE; ANTIBACTERIAL; ROTATION; PYRROLE; ISOMERS; AMIDE;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel series of 1,3-disubstituted pyrrolidinone derivatives with aromatic, hydrazone, azole, diazole and triazole moieties has been prepared from 3-carbohydrazides of 1-phenyl-5-oxopyrrolidine and 1-(4-bromophenyl)-5-oxopyrrolidine. The structure of all the study compounds has been confirmed on the basis of NMR, IR, mass spectra, and elemental analyses data. In some cases, molecular modeling was used for determining the spatial structure.

引用

页码：52 / 60

页数：9

共 48 条

[1] Synthesis of Bis-Pyrrole Tetra Esters and Alcohols as Novel Mimetics of the Anticancer Mitomycin [J].

Abdulla, Zubair M. ;

Iyer, Radhakrishnan P. ;

Akamanchi, Krishnamachari G. ;

Degani, Mariam S. ;

Coutinho, Evans C. .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2011, 48 (01) :38-49

[2] Study of conformations and hydrogen bonds in the configurational isomers of pyrrole-2-carbaldehyde oxime by 1H, 13C and 15N NMR spectroscopy combined with MP2 and DFT calculations and NBO analysis [J].

Afonin, Andrei V. ;

Ushakov, Igor A. ;

Pavlov, Dmitry V. ;

Ivanov, Andrei V. ;

Mikhaleva, Al'bina I. .

MAGNETIC RESONANCE IN CHEMISTRY, 2010, 48 (09) :685-692

[3] Synthesis, Antimicrobial, and Anti-inflammatory Activities of Novel 5-(1-Adamantyl)-4-arylideneamino-3-mercapto-1,2,4-triazoles and Related Derivatives [J].

Al-Omar, Mohamed A. ;

Al-Abdullah, Ebtehal S. ;

Shehata, Ihsan A. ;

Habib, Elsayed E. ;

Ibrahim, Tarek M. ;

El-Emam, Ali A. .

MOLECULES, 2010, 15 (04) :2526-2550

[4]

Ali KA, 2011, ACTA POL PHARM, V68, P237

[5] EFFECTS OF PROTONATION AND HYDROGEN-BONDING ON C-13 CHEMICAL-SHIFTS OF COMPOUNDS CONTAINING THE C=N-GROUP [J].

ALLEN, M ;

ROBERTS, JD .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1981, 59 (02) :451-458

[6]

[Anonymous], 2010, HDB HETEROCYCLIC CHE

[7]

Anusevicius K, 2010, CHEMIJA, V21, P127

[8] C-13 NMR-STUDY OF SOME DERIVATIVES OF 1,3,4-OXADIAZOLES, 1,3,4-THIADIAZOLES AND ISOSYDNONES [J].

ARANDA, G ;

DESSOLIN, M ;

GOLFIER, M ;

GUILLEREZ, MG .

ORGANIC MAGNETIC RESONANCE, 1982, 18 (03) :159-164

[9]

Arora S.K., 2010, U.S. Patent, Patent No. [7,763,602, 7763602]

[10] Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities [J].

Bayrak, Hacer ;

Demirbas, Ahmet ;

Demirbas, Neslihan ;

Karaoglu, Senguel Alpay .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (11) :4362-4366

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