ZrOCl2•8H2O:: an efficient Lewis acid catalyst for the one-pot multicomponent synthesis of β-acetamido ketones

被引：104

作者：

Ghosh, R ^{[1
]}

Maiti, S

Chakraborty, A

Chakraborty, S

Mukherjee, AK

机构：

[1] Jadavpur Univ, Dept Chem, Kolkata 700032, W Bengal, India

[2] Jadavpur Univ, Dept Phys, Kolkata 700032, W Bengal, India

来源：

TETRAHEDRON | 2006年 / 62卷 / 17期

关键词：

one-pot multicomponent synthesis; ZrOCl2 center dot 8H(2)O; Lewis acid catalyzed; beta-acetamido ketone;

D O I：

10.1016/j.tet.2006.02.037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aromatic aldehydes were reacted in one-pot with enolisable ketones, acetonitrile and acctyl chloride at ambient temperature in the presence of ZrOCl2 center dot 8H(2)O to furnish the corresponding beta-acetamido ketones in very good to excellent yields. X-ray crystallographic analysis of one anti-beta-acetamido ketone exhibited a two-dimensional supramolecular framework by a combination of N-H center dot center dot center dot O, C-H center dot center dot center dot O and C-H center dot center dot center dot pi (arene) hydrogen bonds. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4059 / 4064

页数：6

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