Pivotal role for TGF-β in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy

被引：59

作者：

Araujo-Jorge, Tania C. ^{[1
]}

Waghabi, Mariana C. ^{[1
,2
]}

Soeiro, Maria de Nazar C. ^{[1
]}

Keramidas, Michelle ^{[3
,4
,5
]}

Bailly, Sabine ^{[3
,4
,5
]}

Feige, Jean-Jacques ^{[3
,4
,5
]}

机构：

[1] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Biol Celular, BR-21045900 Rio De Janeiro, Brazil

[2] Inst Oswaldo Cruz, Lab Genome Func & Bioinformat, BR-21045 Rio De Janeiro, Brazil

[3] CEA Grenoble, IRTSV LAPV, Unite 878, INSERM, F-38045 Grenoble 9, France

[4] Inst Rech Technol & Sci Vivant, CEA, F-38054 Grenoble, France

[5] Univ Grenoble 1, Grenoble, France

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2008年 / 19卷 / 5-6期

关键词：

TGF-beta; Chagas disease; Trypanosoma cruzi; Cardiac fibrosis;

D O I：

10.1016/j.cytogfr.2008.08.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper summarizes recent data from the literature suggesting that transforming growth factor-P (TGF-beta) participates at least in four different processes influencing development of myocardiopathy in Chagas disease, a major parasitic illness caused by Trypanosoma cruzi infection: (a) invasion of cardiac fibroblasts and myocytes; (b) intracellular parasite cycle; (c) regulation of inflammation and immune response; (d) fibrosis and heart remodeling during acute and chronic disease. All these effects point to an important role of TGF-beta in Chagas 7 disease myocardiopathy and suggest that monitoring the circulating levels of this cytokine could be of help in clinical prognosis and management of patients. Moreover, TGF-beta-interfering therapies appear as interesting adjuvant interventions during acute and chronic phases of T cruzi infection. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：405 / 413

页数：9

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